Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/21800
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dc.contributor.authorJackson, Melinda L-
dc.contributor.authorTolson, Julie-
dc.contributor.authorBartlett, Delwyn-
dc.contributor.authorBerlowitz, David J-
dc.contributor.authorVarma, Prerna-
dc.contributor.authorBarnes, Maree-
dc.date2019-03-27-
dc.date.accessioned2019-09-23T04:43:01Z-
dc.date.available2019-09-23T04:43:01Z-
dc.date.issued2019-10-
dc.identifier.citationSleep Medicine 2019; 62: 22-28en_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/21800-
dc.description.abstractPatients with obstructive sleep apnea (OSA) experience daytime sleepiness, cognitive impairment and depressive symptoms. However, the measured prevalence of clinical depression in OSA using standardized clinical assessment is currently unclear. The aims of this study were to examine the prevalence of clinical depression and antidepressant use in untreated OSA patients, to examine predictors of depression, and to conduct an exploratory meta-analysis to determine the pooled prevalence of clinical depression in this population. In sum, 109 consecutive patients with diagnosed OSA (mean age (SD) = 52.6 (12.1) years; 43.1% female) who presented to the sleep laboratory completed a structured clinical interview for depression (SCID-IV), the Hospital Anxiety and Depression Scale, the Pittsburgh Sleep Quality Index (PSQI), the Functional Outcomes of Sleep Questionnaire (FOSQ), the Assessment of Quality of Life Questionnaire (AQoL) and the Epworth Sleepiness Scale (EES). An exploratory meta-analysis was also conducted to quantify the risk of clinical depression in untreated OSA. Twenty-five (22.7%) participants had clinical depression based on the SCID-IV, and 24.8% were using antidepressants. Those with clinical depression had significantly poorer sleep quality and impaired quality of life. In a regression model, quality of life impairment was most strongly associated with clinical depression. Results from the meta-analysis revealed a pooled prevalence of 23% of clinical depression in OSA patients across seven studies. Clinical depression and antidepressant use is common in patients with OSA. Depression was associated with reduced quality of life and poorer subjective sleep, however it was not associated with polysomnographic measures or daytime sleepiness. Whether CPAP treatment can alleviate the burden of clinical depression needs to be determined in future studies.en_US
dc.language.isoeng-
dc.subjectExcessive daytime sleepinessen_US
dc.subjectMajor depressive disorderen_US
dc.subjectMeta-analysisen_US
dc.subjectMooden_US
dc.subjectQuality of lifeen_US
dc.subjectSleep apneaen_US
dc.titleClinical depression in untreated obstructive sleep apnea: examining predictors and a meta-analysis of prevalence rates.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleSleep Medicineen_US
dc.identifier.affiliationRMIT University, School of Health and Biomedical Science, Bundoora, Melbourne, Australiaen_US
dc.identifier.affiliationInstitute for Breathing and Sleepen_US
dc.identifier.affiliationWoolcock Institute for Medical Research, Sydney, Australiaen_US
dc.identifier.affiliationPhysiotherapyen_US
dc.identifier.affiliationThe University of Melbourne, Melbourne, Australiaen_US
dc.identifier.doi10.1016/j.sleep.2019.03.011en_US
dc.type.contentTexten_US
dc.identifier.orcid0000-0003-2543-8722en_US
dc.identifier.pubmedid31525678-
dc.type.austinJournal Article-
local.name.researcherBarnes, Maree
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptInstitute for Breathing and Sleep-
crisitem.author.deptRespiratory and Sleep Medicine-
crisitem.author.deptPhysiotherapy-
crisitem.author.deptInstitute for Breathing and Sleep-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
crisitem.author.deptInstitute for Breathing and Sleep-
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