Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/21787
Title: Non-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in Alzheimer's disease.
Authors: Hadoux, Xavier;Hui, Flora;Lim, Jeremiah K H;Masters, Colin L;Pébay, Alice;Chevalier, Sophie;Ha, Jason;Loi, Samantha;Fowler, Christopher J;Rowe, Christopher C;Villemagne, Victor L;Taylor, Edward N;Fluke, Christopher;Soucy, Jean-Paul;Lesage, Frédéric;Sylvestre, Jean-Philippe;Rosa-Neto, Pedro;Mathotaarachchi, Sulantha;Gauthier, Serge;Nasreddine, Ziad S;Arbour, Jean Daniel;Rhéaume, Marc-André;Beaulieu, Sylvain;Dirani, Mohamed;Nguyen, Christine T O;Bui, Bang V;Williamson, Robert;Crowston, Jonathan G;van Wijngaarden, Peter
Affiliation: Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, 3800, VIC, Australia
Research Center, Montreal Heart Institute, Montreal, H1T 1C8, QC, Canada
Centre for Astrophysics and Supercomputing, Swinburne University of Technology, Melbourne, 3122, VIC, Australia
McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, H3A 2B4, QC, Canada
PERFORM Centre, Concordia University, Montreal, H4B 1R6, QC, Canada
Translational Neuroimaging Laboratory, McGill Centre for Studies in Aging, Douglas Mental Health University Institute, Montreal, H4H 1R3, QC, Canada
Alzheimer's Disease Research Unit, The McGill University Research Centre for Studies in Aging, McGill University, Montreal, H4H 1R3, QC, Canada
École Polytechnique de Montréal, Institut de génie biomédical, Département de Génie électrique, Montreal, H3C 3A7, QC, Canada
Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, 3002, VIC, Australia
Ophthalmology, Department of Surgery, University of Melbourne, Parkville, 3010, VIC, Australia
Murdoch Children's Research Institute and Department of Paediatrics, University of Melbourne, Melbourne, 3052, VIC, Australia
Department of Optometry and Vision Sciences, University of Melbourne, Parkville, 3010, VIC, Australia
Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, 169856, Singapore
OzGrav-Swinburne, Centre for Astrophysics & Supercomputing, Swinburne University of Technology, Melbourne, 3122, VIC, Australia
Advanced Visualisation Laboratory, Digital Research Innovation Capability Platform, Swinburne University of Technology, Melbourne, 3122, VIC, Australia
Austin Health, Heidelberg, Victoria, Australia
The Florey Institute, The University of Melbourne, Parkville, 3010, VIC, Australia
Neuropsychiatry Unit, North Western Mental Health, Melbourne Health, Royal Melbourne Hospital, Parkville, 3050, VIC, Australia
University of Melbourne, Department of Psychiatry, Parkville, 3010, VIC, Australia
Optina Diagnostics, Montreal, H4T 1Z2, QC, Canada
Alzheimer's Disease Research Unit, The McGill University Research Centre for Studies in Aging, McGill University, Montreal, H4H 1R3, QC, Canada
MoCA Clinic and Institute, Greenfield Park, J4V 2J2, QC, Canada
Clinique ophtalmologique 2121, Montreal, H3H 1G6, QC, Canada
Département de médecine nucléaire, Hôpital Maisonneuve-Rosemont, Montreal, H1T 2M4, QC, Canada
Issue Date: 17-Sep-2019
EDate: 2019-09-17
Citation: Nature communications 2019; 10(1): 4227
Abstract: Studies of rodent models of Alzheimer's disease (AD) and of human tissues suggest that the retinal changes that occur in AD, including the accumulation of amyloid beta (Aβ), may serve as surrogate markers of brain Aβ levels. As Aβ has a wavelength-dependent effect on light scatter, we investigate the potential for in vivo retinal hyperspectral imaging to serve as a biomarker of brain Aβ. Significant differences in the retinal reflectance spectra are found between individuals with high Aβ burden on brain PET imaging and mild cognitive impairment (n = 15), and age-matched PET-negative controls (n = 20). Retinal imaging scores are correlated with brain Aβ loads. The findings are validated in an independent cohort, using a second hyperspectral camera. A similar spectral difference is found between control and 5xFAD transgenic mice that accumulate Aβ in the brain and retina. These findings indicate that retinal hyperspectral imaging may predict brain Aβ load.
URI: http://ahro.austin.org.au/austinjspui/handle/1/21787
DOI: 10.1038/s41467-019-12242-1
ORCID: 0000-0002-4524-3706
0000-0003-2218-9951
0000-0002-4694-9479
0000-0002-7408-9453
0000-0002-4953-4500
0000-0003-0961-2321
0000-0001-9116-1376
0000-0002-3298-3086
0000-0003-3910-2453
PubMed URL: 31530809
Type: Journal Article
Appears in Collections:Journal articles

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