Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/20881
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dc.contributor.authorCursons, Joseph-
dc.contributor.authorSouza-Fonseca-Guimaraes, Fernando-
dc.contributor.authorForoutan, Momeneh-
dc.contributor.authorAnderson, Ashley-
dc.contributor.authorHollande, Frédéric-
dc.contributor.authorHediyeh-Zadeh, Soroor-
dc.contributor.authorBehren, Andreas-
dc.contributor.authorHuntington, Nicholas D-
dc.contributor.authorDavis, Melissa J-
dc.date2019-05-14-
dc.date.accessioned2019-06-05T01:28:45Z-
dc.date.available2019-06-05T01:28:45Z-
dc.date.issued2019-07-
dc.identifier.citationCancer immunology research 2019; 7(7): 1162-1174en
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/20881-
dc.description.abstractNatural killer (NK) cell activity is essential for initiating antitumor responses and may be linked to immunotherapy success. NK cells and other innate immune components could be exploitable for cancer treatment, which drives the need for tools and methods that identify therapeutic avenues. Here, we extend our gene-set scoring method singscore to investigate NK cell infiltration by applying RNA-seq analysis to samples from bulk tumors. Computational methods have been developed for the deconvolution of immune cell types within solid tumors. We have taken the NK cell gene signatures from several such tools, then curated the gene list using a comparative analysis of tumors and immune cell types. Using a gene-set scoring method to investigate RNA-seq data from The Cancer Genome Atlas (TCGA), we show that patients with metastatic cutaneous melanoma have an improved survival rate if their tumor shows evidence of NK cell infiltration. Furthermore, these survival effects are enhanced in tumors that show higher expression of genes that encode NK cell stimuli such as the cytokine IL15 Using this signature, we then examine transcriptomic data to identify tumor and stromal components that may influence the penetrance of NK cells into solid tumors. Our results provide evidence that NK cells play a role in the regulation of human tumors and highlight potential survival effects associated with increased NK cell activity. Our computational analysis identifies putative gene targets that may be of therapeutic value for boosting NK cell antitumor immunity.en
dc.language.isoeng-
dc.titleA Gene Signature Predicting Natural Killer Cell Infiltration and Improved Survival in Melanoma Patients.en
dc.typeJournal Articleen
dc.identifier.journaltitleCancer immunology researchen
dc.identifier.affiliationBioinformatics Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australiaen
dc.identifier.affiliationDepartment of Biochemistry, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, Victoria, Australiaen
dc.identifier.affiliationBiomedicine Discovery Institute and the Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australiaen
dc.identifier.affiliationOlivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationSchool of Cancer Medicine, La Trobe University, Melbourne, Victoria, Australiaen
dc.identifier.affiliationDepartment of Clinical Pathology, The University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Melbourne, Victoria, Australiaen
dc.identifier.affiliationDivision of Molecular Immunology, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australiaen
dc.identifier.affiliationDepartment of Medical Biology, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, Victoria, Australiaen
dc.identifier.doi10.1158/2326-6066.CIR-18-0500en
dc.type.contentTexten
dc.identifier.orcid0000-0002-5053-4540en
dc.identifier.orcid0000-0002-1440-0457en
dc.identifier.orcid0000-0002-6981-346Xen
dc.identifier.orcid0000-0001-7513-6779en
dc.identifier.orcid0000-0001-5329-280Xen
dc.identifier.orcid0000-0002-5267-7211en
dc.identifier.pubmedid31088844-
dc.type.austinJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
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