Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/20814
Title: Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.
Authors: Malik, Rainer;Chauhan, Ganesh;Traylor, Matthew;Sargurupremraj, Muralidharan;Okada, Yukinori;Mishra, Aniket;Rutten-Jacobs, Loes;Giese, Anne-Katrin;van der Laan, Sander W;Gretarsdottir, Solveig;Anderson, Christopher D;Anderson, Christopher D;Chong, Michael;Adams, Hieab H H;Ago, Tetsuro;Almgren, Peter;Amouyel, Philippe;Ay, Hakan;Bartz, Traci M;Benavente, Oscar R;Bevan, Steve;Salomaa, Veikko;Bevan, Steve;Boncoraglio, Giorgio B;Brown, Robert D;Butterworth, Adam S;Carrera, Caty;Carty, Cara L;Chasman, Daniel I;Chen, Wei-Min;Cole, John W;Correa, Adolfo;Sapkota, Bishwa R;Boncoraglio, Giorgio B;Cotlarciuc, Ioana;Cruchaga, Carlos;Danesh, John;de Bakker, Paul I W;DeStefano, Anita L;Hoed, Marcel den;Duan, Qing;Engelter, Stefan T;Falcone, Guido J;Schmidt, Reinhold;Gottesman, Rebecca F;Brown, Robert D;Grewal, Raji P;Gudnason, Vilmundur;Gustafsson, Stefan;Haessler, Jeffrey;Harris, Tamara B;Hassan, Ahamad;Havulinna, Aki S;Heckbert, Susan R;Schmidt, Carsten O;Holliday, Elizabeth G;Howard, George;Butterworth, Adam S;Hsu, Fang-Chi;Hyacinth, Hyacinth I;Ikram, M Arfan;Ingelsson, Erik;Irvin, Marguerite R;Jian, Xueqiu;Jiménez-Conde, Jordi;Schminke, Ulf;Johnson, Julie A;Jukema, J Wouter;Kanai, Masahiro;Carrera, Caty;Keene, Keith L;Kissela, Brett M;Kleindorfer, Dawn O;Kooperberg, Charles;Kubo, Michiaki;Lange, Leslie A;Sharma, Pankaj;Langefeld, Carl D;Langenberg, Claudia;Launer, Lenore J;Lee, Jin-Moo;Carty, Cara L;Lemmens, Robin;Leys, Didier;Lewis, Cathryn M;Lin, Wei-Yu;Lindgren, Arne G;Slowik, Agnieszka;Lorentzen, Erik;Magnusson, Patrik K;Maguire, Jane;Manichaikul, Ani;McArdle, Patrick F;Chasman, Daniel I;Meschia, James F;Mitchell, Braxton D;Mosley, Thomas H;Nalls, Michael A;Sudlow, Cathie L M;Ninomiya, Toshiharu;O'Donnell, Martin J;Psaty, Bruce M;Pulit, Sara L;Rannikmäe, Kristiina;Reiner, Alexander P;Chen, Wei-Min;Rexrode, Kathryn M;Rice, Kenneth;Rich, Stephen S;Tanislav, Christian;Ridker, Paul M;Rost, Natalia S;Rothwell, Peter M;Rotter, Jerome I;Rundek, Tatjana;Sacco, Ralph L;Sakaue, Saori;Cole, John W;Sale, Michele M;Salomaa, Veikko;Tatlisumak, Turgut;Sapkota, Bishwa R;Schmidt, Reinhold;Schmidt, Carsten O;Schminke, Ulf;Sharma, Pankaj;Slowik, Agnieszka;Sudlow, Cathie L M;Tanislav, Christian;Correa, Adolfo;Tatlisumak, Turgut;Chong, Michael;Taylor, Kent D;Thijs, Vincent N S;Thorleifsson, Gudmar;Thorsteinsdottir, Unnur;Tiedt, Steffen;Trompet, Stella;Tzourio, Christophe;van Duijn, Cornelia M;Walters, Matthew;Cotlarciuc, Ioana;Taylor, Kent D;Wareham, Nicholas J;Wassertheil-Smoller, Sylvia;Wilson, James G;Wiggins, Kerri L;Yang, Qiong;Yusuf, Salim;Amin, Najaf;Aparicio, Hugo S;Arnett, Donna K;Attia, John;Thijs, Vincent N S;Cruchaga, Carlos;Beiser, Alexa S;Berr, Claudine;Buring, Julie E;Bustamante, Mariana;Caso, Valeria;Cheng, Yu-Ching;Choi, Seung Hoan;Chowhan, Ayesha;Cullell, Natalia;Thorleifsson, Gudmar;Dartigues, Jean-François;Danesh, John;Delavaran, Hossein;Delgado, Pilar;Dörr, Marcus;Engström, Gunnar;Ford, Ian;Gurpreet, Wander S;Hamsten, Anders;Heitsch, Laura;Thorsteinsdottir, Unnur;Hozawa, Atsushi;Ibanez, Laura;de Bakker, Paul I W;Ilinca, Andreea;Ingelsson, Martin;Iwasaki, Motoki;Jackson, Rebecca D;Jood, Katarina;Jousilahti, Pekka;Kaffashian, Sara;Tiedt, Steffen;Kalra, Lalit;Kamouchi, Masahiro;Kitazono, Takanari;DeStefano, Anita L;Kjartansson, Olafur;Kloss, Manja;Koudstaal, Peter J;Krupinski, Jerzy;Labovitz, Daniel L;Laurie, Cathy C;Trompet, Stella;Levi, Christopher R;Li, Linxin;Lind, Lars;Lindgren, Cecilia M;den Hoed, Marcel;Lioutas, Vasileios;Liu, Yong Mei;Lopez, Oscar L;Makoto, Hirata;Martinez-Majander, Nicolas;Tzourio, Christophe;Matsuda, Koichi;Minegishi, Naoko;Montaner, Joan;Morris, Andrew P;Muiño, Elena;Duan, Qing;Müller-Nurasyid, Martina;Norrving, Bo;Ogishima, Soichi;Parati, Eugenio A;van Duijn, Cornelia M;Peddareddygari, Leema Reddy;Pedersen, Nancy L;Pera, Joanna;Perola, Markus;Pezzini, Alessandro;Pileggi, Silvana;Engelter, Stefan T;Rabionet, Raquel;Riba-Llena, Iolanda;Ribasés, Marta;Walters, Matthew;Romero, Jose R;Roquer, Jaume;Rudd, Anthony G;Sarin, Antti-Pekka;Sarju, Ralhan;Sarnowski, Chloe;Sasaki, Makoto;Falcone, Guido J;Satizabal, Claudia L;Satoh, Mamoru;Wareham, Nicholas J;Sattar, Naveed;Sawada, Norie;Sibolt, Gerli;Sigurdsson, Ásgeir;Smith, Albert;Sobue, Kenji;Soriano-Tárraga, Carolina;Stanne, Tara;Gottesman, Rebecca F;Stine, O Colin;Adams, Hieab H H;Stott, David J;Strauch, Konstantin;Takai, Takako;Tanaka, Hideo;Tanno, Kozo;Teumer, Alexander;Tomppo, Liisa;Torres-Aguila, Nuria P;Touze, Emmanuel;Grewal, Raji P;Wassertheil-Smoller, Sylvia;Tsugane, Shoichiro;Uitterlinden, Andre G;Valdimarsson, Einar M;van der Lee, Sven J;Völzke, Henry;Wakai, Kenji;Weir, David;Williams, Stephen R;Wolfe, Charles D A;Wong, Quenna;Wilson, James G;Gudnason, Vilmundur;Xu, Huichun;Yamaji, Taiki;Sanghera, Dharambir K;Melander, Olle;Jern, Christina;Strbian, Daniel;Fernandez-Cadenas, Israel;Longstreth, W T;Rolfs, Arndt;Wiggins, Kerri L;Hata, Jun;Gustafsson, Stefan;Woo, Daniel;Rosand, Jonathan;Pare, Guillaume;Hopewell, Jemma C;Saleheen, Danish;Stefansson, Kari;Worrall, Bradford B;Kittner, Steven J;Yang, Qiong;Seshadri, Sudha;Fornage, Myriam;Haessler, Jeffrey;Markus, Hugh S;Howson, Joanna M M;Kamatani, Yoichiro;Debette, Stephanie;Dichgans, Martin;Harris, Tamara B;Hassan, Ahamad;Yusuf, Salim;Havulinna, Aki S;Heckbert, Susan R;Holliday, Elizabeth G;Howard, George;Hsu, Fang-Chi;Hyacinth, Hyacinth I;Ikram, M Arfan;Ingelsson, Erik;Irvin, Marguerite R;Jian, Xueqiu;Bis, Joshua C;Jiménez-Conde, Jordi;Johnson, Julie A;Jukema, J Wouter;Kanai, Masahiro;Keene, Keith L;Kissela, Brett M;Kleindorfer, Dawn O;Kooperberg, Charles;Kubo, Michiaki;Lange, Leslie A;Pastinen, Tomi;Langefeld, Carl D;Langenberg, Claudia;Launer, Lenore J;Lee, Jin-Moo;Lemmens, Robin;Leys, Didier;Lewis, Cathryn M;Lin, Wei-Yu;Lindgren, Arne G;Lorentzen, Erik;Ruusalepp, Arno;Magnusson, Patrik K;Maguire, Jane;Manichaikul, Ani;McArdle, Patrick F;Meschia, James F;Mitchell, Braxton D;Mosley, Thomas H;Nalls, Michael A;Ninomiya, Toshiharu;O'Donnell, Martin J;Schadt, Eric E;Psaty, Bruce M;Pulit, Sara L;Rannikmäe, Kristiina;Reiner, Alexander P;Rexrode, Kathryn M;Rice, Kenneth;Rich, Stephen S;Ridker, Paul M;Rost, Natalia S;Rothwell, Peter M;Koplev, Simon;Rotter, Jerome I;Rundek, Tatjana;Sacco, Ralph L;Sakaue, Saori;Sale, Michele M;Ago, Tetsuro;Björkegren, Johan L M;Codoni, Veronica;Civelek, Mete;Smith, Nicholas L;Trégouët, David A;Christophersen, Ingrid E;Roselli, Carolina;Lubitz, Steven A;Ellinor, Patrick T;Tai, E Shyong;Almgren, Peter;Kooner, Jaspal S;Kato, Norihiro;He, Jiang;van der Harst, Pim;Elliott, Paul;Chambers, John C;Takeuchi, Fumihiko;Johnson, Andrew D;Sanghera, Dharambir K;Melander, Olle;Amouyel, Philippe;Jern, Christina;Strbian, Daniel;Fernandez-Cadenas, Israel;Longstreth, W T;Rolfs, Arndt;Hata, Jun;Woo, Daniel;Rosand, Jonathan;Pare, Guillaume;Hopewell, Jemma C;Ay, Hakan;Saleheen, Danish;Stefansson, Kari;Worrall, Bradford B;Kittner, Steven J;Seshadri, Sudha;Fornage, Myriam;Markus, Hugh S;Howson, Joanna M M;Kamatani, Yoichiro;Debette, Stephanie;Bartz, Traci M;Dichgans, Martin;Malik, Rainer;Chauhan, Ganesh;Traylor, Matthew;Sargurupremraj, Muralidharan;Okada, Yukinori;Mishra, Aniket;Rutten-Jacobs, Loes;Giese, Anne-Katrin;van der Laan, Sander W;Benavente, Oscar R;Gretarsdottir, Solveig
Affiliation: Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany
Division of Cardiovascular Medicine, College of Medicine, University of Florida, Gainesville, FL, USA
Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida, College of Pharmacy, Gainesville, FL, USA
Department of Neurology, Yale University School of Medicine, New Haven, CT, USA
Harvard Medical School, Boston, MA, USA
Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA
Center for Translational Science, George Washington University, Washington, DC, USA
Children's Research Institute, Children's National Medical Center, Washington, DC, USA
AA Martinos Center for Biomedical Imaging, Department of Radiology, MGH, Harvard Medical School, Boston, MA, USA
Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA
J. Philip Kistler Stroke Research Center, Department of Neurology, MGH, Boston, MA, USA
Boston University School of Medicine, Boston, MA, USA
Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA
Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA
Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA, USA
Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA
Department of Health Services, University of Washington, Seattle, WA, USA
Center for Health Disparities, East Carolina University, Greenville, NC, USA
British Heart Foundation, Cambridge Centre of Excellence, Department of Medicine, University of Cambridge, Cambridge, UK
Department of Biology, East Carolina University, Greenville, NC, USA
Laboratory of Epidemiology and Population Science, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany
Program in Bioinformatics and Integrative Genomics, Harvard Medical School, Boston, MA, USA
INSERM U1219 Bordeaux Population Health Research Center, University of Bordeaux, France
Laboratory of Experimental Cardiology, Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, University of Utrecht, Utrecht, the Netherlands
deCODE genetics/AMGEN Inc., Reykjavik, Iceland
Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Department of Clinical Sciences, Lund University, Malmö, Sweden
School of Life Science, University of Lincoln, Lincoln, UK
Department of Cerebrovascular Diseases, Fondazione IRCCS Istituto Neurologico 'Carlo Besta', Milan, Italy
Institute of Cardiovascular Research, Royal Holloway University of London, London, UK, and Ashford and St Peters Hospital, Surrey, UK
School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
Department of Immunology, Genetics and Pathology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden
Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden
Department of Neurology, Leeds General Infirmary, Leeds Teaching Hospitals NHS Trust, Leeds, UK
Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands
Neurovascular Research Group (NEUVAS), Neurology Department, Institut Hospital del Mar d'Investigació Mèdica, Universitat Autònoma de Barcelona, Barcelona, Spain
Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands
RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, UK
INSERM U 1171, CHU Lille, Université Lille, Lille, France
Bioinformatics Core Facility, University of Gothenburg, Gothenburg, Sweden
Department of Biostatistics, University of Liverpool, Liverpool, UK
Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK
National Institute for Health and Welfare, Helsinki, Finland
Institute for Community Medicine, SHIP-KEF, University Medicine Greifswald, Greifswald, Germany
Department of Neurology, University Medicine Greifswald, Greifswald, Germany
Institute of Cardiovascular Research, Royal Holloway University of London, London, UK, and Ashford and St Peters Hospital, Surrey, UK
Department of Neurology, Jagiellonian University, Krakow, Poland
Department of Neurology, Justus Liebig University, Giessen, Germany
Karolinska Institutet, Stockholm, Sweden
deCODE genetics/AMGEN Inc., Reykjavik, Iceland
Aflac Cancer and Blood Disorder Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA
deCODE genetics/AMGEN Inc., Reykjavik, Iceland
Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany
Department of Internal Medicine, Section Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands
School of Medicine, Dentistry and Nursing at the University of Glasgow, Glasgow, UK
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, UK
Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore
National Heart and Lung Institute, Imperial College London, London, UK
Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan
Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden
Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
MRC-PHE Centre for Environment and Health, School of Public Health, Department of Epidemiology and Biostatistics and the NIHR Imperial Biomedical Research Centre, Imperial College London, London, UK
Department of Medical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands
Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan
Department of Clinical Sciences, Lund University, Malmö, Sweden
Department of Pathology and Genetics, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
Albrecht Kossel Institute, University Clinic of Rostock, Rostock, Germany
Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK
INSERM U1219 Bordeaux Population Health Research Center, University of Bordeaux, France
DZHK, Greifswald, Germany
MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany
INSERM U1219 Bordeaux Population Health Research Center, University of Bordeaux, France
Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA
INSERM U1219 Bordeaux Population Health Research Center, University of Bordeaux, France
Laboratory of Experimental Cardiology, Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, University of Utrecht, Utrecht, the Netherlands
deCODE genetics/AMGEN Inc., Reykjavik, Iceland
Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Department of Clinical Sciences, Lund University, Malmö, Sweden
School of Life Science, University of Lincoln, Lincoln, UK
Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany
Department of Cerebrovascular Diseases, Fondazione IRCCS Istituto Neurologico 'Carlo Besta', Milan, Italy
Institute of Cardiovascular Research, Royal Holloway University of London, London, UK, and Ashford and St Peters Hospital, Surrey, UK
Department of Immunology, Genetics and Pathology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden
Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Department of Neurology, Leeds General Infirmary, Leeds Teaching Hospitals NHS Trust, Leeds, UK
Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands
Neurovascular Research Group (NEUVAS), Neurology Department, Institut Hospital del Mar d'Investigació Mèdica, Universitat Autònoma de Barcelona, Barcelona, Spain
Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands
RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
Department of Neurology, Memory Clinic, Bordeaux University Hospital, Bordeaux, France
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, UK
INSERM U 1171, CHU Lille, Université Lille, Lille, France
Bioinformatics Core Facility, University of Gothenburg, Gothenburg, Sweden
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA
Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK
National Institute for Health and Welfare, Helsinki, Finland
Institute for Community Medicine, SHIP-KEF, University Medicine Greifswald, Greifswald, Germany
Department of Neurology, University Medicine Greifswald, Greifswald, Germany
Bordeaux Population Health Research Center, INSERM, UMR 1219, Université Bordeaux, Bordeaux, France
Institute of Cardiovascular Research, Royal Holloway University of London, London, UK, and Ashford and St Peters Hospital, Surrey, UK
Department of Neurology, Jagiellonian University, Krakow, Poland
Department of Neurology, Justus Liebig University, Giessen, Germany
deCODE genetics/AMGEN Inc., Reykjavik, Iceland
Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany
Center for Public Health Genomics and Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA
Department of Internal Medicine, Section Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands
School of Medicine, Dentistry and Nursing at the University of Glasgow, Glasgow, UK
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, UK
Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands
German Center for Neurodegenerative Diseases (DZNE), Munich, Germany
INSERM, U1061, Université Montpellier, Montpellier, France
Centre for Research in Environmental Epidemiology, Barcelona, Spain
Department of Neurology, Università degli Studi di Perugia, Umbria, Italy
Stroke Pharmacogenomics and Genetics, Fundacio Docència i Recerca MutuaTerrassa, Terrassa, Spain
Neurovascular Research Laboratory. Vall d'Hebron Institut of Research, Neurology and Medicine Departments-Universitat Autònoma de Barcelona. Vall d'Hebrón Hospital, Barcelona, Spain
Department of Clinical Sciences, Lund University, Malmö, Sweden
Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
Robertson Center for Biostatistics, University of Glasgow, Glasgow, UK
Tohoku Medical Megabank Organization, Sendai, Japan
Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden
Center for Genomic Medicine, MGH, Boston, MA, USA
Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan
Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Goteborg, Sweden
National Institute for Health and Welfare, Helsinki, Finland
Department of Basic and Clinical Neurosciences, King's College London, London, UK
Department of Health Care Administration and Management, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Departments of Neurology & Radiology, Landspitali National University Hospital, Reykjavik, Iceland
Department of Neurology, Radiology, and Biomedical Engineering, Washington University School of Medicine, St. Louis, MO, USA
Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany
Department of Neurology, Erasmus University Medical Center, Rotterdam, the Netherlands
Munich Cluster for Systems Neurology (SyNergy), Munich, Germany
Hospital Universitari Mutua Terrassa, Terrassa (Barcelona), Spain
Centre for Prevention of Stroke and Dementia, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK
Department of Medical Sciences, Uppsala University, Uppsala, Sweden
BioBank Japan, Laboratory of Clinical Sequencing, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan
Department of Neurology, Helsinki University Hospital, Helsinki, Finland
BioBank Japan, Laboratory of Clinical Sequencing, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan
Tohoku Medical Megabank Organization, Sendai, Japan
Neurovascular Research Laboratory, Vall d'Hebron Institut of Research, Neurology and Medicine Departments-Universitat Autònoma de Barcelona, Vall d'Hebrón Hospital, Barcelona, Spain
Department of Neurology, Mayo Clinic, Jacksonville, FL, USA
Stroke Pharmacogenomics and Genetics, Fundacio Docència i Recerca MutuaTerrassa, Terrassa, Spain
Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany
Tohoku Medical Megabank Organization, Sendai, Japan
Department of Cerebrovascular Diseases, Fondazione IRCCS Istituto Neurologico 'Carlo Besta', Milan, Italy
Department of Neurology, Jagiellonian University, Krakow, Poland
Department of Clinical and Experimental Sciences, Neurology Clinic, University of Brescia, Brescia, Italy
Translational Genomics Unit, Department of Oncology, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
Department of Genetics, Microbiology and Statistics, University of Barcelona, Barcelona, Spain
Neurovascular Research Laboratory, Vall d'Hebron Institut of Research, Neurology and Medicine Departments-Universitat Autònoma de Barcelona, Vall d'Hebrón Hospital, Barcelona, Spain
Psychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addictions, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Biomedical Network Research Centre on Mental Health (CIBERSAM), Barcelona, Spain
Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, Japan
Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, USA
Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, Japan
BHF Glasgow Cardiovascular Research Centre, Faculty of Medicine, Glasgow, UK
Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan
Department of Neurology, Helsinki University Hospital, Helsinki, Finland
deCODE Genetics/Amgen, Inc., Reykjavik, Iceland
Icelandic Heart Association, Reykjavik, Iceland
Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, Japan
IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain
Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Goteborg, Sweden
Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Glasgow, UK
deCODE genetics/AMGEN Inc., Reykjavik, Iceland
Memory Impairment and Neurodegenerative Dementia Center, University of Mississippi Medical Center, Jackson, MS, USA
Tohoku Medical Megabank Organization, Sendai, Japan
Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, Japan
Institute for Community Medicine, SHIP-KEF, University Medicine Greifswald, Greifswald, Germany
Department of Neurology, Helsinki University Hospital, Helsinki, Finland
Stroke Pharmacogenomics and Genetics, Fundacio Docència i Recerca MutuaTerrassa, Terrassa, Spain
Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan
Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands
Landspitali University Hospital, Reykjavik, Iceland
Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands
Clinical Neurosciences, Neurology, University of Helsinki, Helsinki, Finland
Institute for Community Medicine, SHIP-KEF, University Medicine Greifswald, Greifswald, Germany
Division of Geriatrics, School of Medicine, University of Mississippi Medical Center, Jackson, MS, USA
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan
Department of Clinical Sciences, Lund University, Malmö, Sweden
Department of Pathology and Genetics, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
Albrecht Kossel Institute, University Clinic of Rostock, Rostock, Germany
Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK
INSERM U1219 Bordeaux Population Health Research Center, University of Bordeaux, France
Department of Neurology, Helsinki University Hospital, Helsinki, Finland
MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
Data Tecnica International, Glen Echo, MD, USA
Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA
Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL, USA
Department of Pediatrics, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, NY, USA
Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA
Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA
Cardiovascular Research Center, MGH, Boston, MA, USA
Department of Cardiology, Ealing Hospital NHS Trust, Southall, UK
Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA
Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands
Seattle Epidemiologic Research and Information Center, VA Office of Research and Development, Seattle, WA, USA
Group Health Research Institute, Group Health Cooperative, Seattle, WA, USA
Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA
Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA
Division of Emergency Medicine, and Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA
Department of Internal Medicine and the Center for Clinical and Translational Science, Ohio State University, Columbus, OH, USA
Montefiore Medical Center, Albert Einstein College of Medicine, New York, NY, USA
Department of Epidemiology and Biostatistics, Imperial College London, London, UK
Wake Forest School of Medicine, Wake Forest, NC, USA
Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA
Neuroscience Institute, SF Medical Center, Trenton, NJ, USA
Department of Epidemiology, University of Maryland School of Medicine, Baltimore, MD, USA
Survey Research Center, University of Michigan, Ann Arbor, MI, USA
Department of Neurology, University of Virginia, Charlottesville, VA, USA
Department of Biostatistics, University of Washington, Seattle, WA, USA
Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
University of Cincinnati College of Medicine, Cincinnati, OH, USA
Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
ICAN Institute for Cardiometabolism and Nutrition, Paris, France
Departments of Neurology and Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, USA
Department of Neurology, University of Maryland School of Medicine and Baltimore VAMC, Baltimore, MD, USA
University of Kentucky College of Public Health, Lexington, KY, USA
University of Newcastle and Hunter Medical Research Institute, New Lambton, New South Wales, Australia
Centre for Brain Research, Indian Institute of Science, Bangalore, India
Department of Human Genetics, McGill University, Montreal, Quebec, Canada
Department of Neurology, Medical University of Graz, Graz, Austria
Department of Neurology, University of Washington, Seattle, WA, USA
Hero DMC Heart Institute, Dayanand Medical College & Hospital, Ludhiana, India
John Hunter Hospital, Hunter Medical Research Institute and University of Newcastle, Newcastle, New South Wales, Australia
UPMC Univ. Paris 06, INSERM, UMR_S 1166, Team Genomics & Pathophysiology of Cardiovascular Diseases, Sorbonne Universités, Paris, France
Department of Epidemiology, University of Washington, Seattle, WA, USA
University of Technology Sydney, Faculty of Health, Ultimo, New South Wales, Australia
Division of Neurology, Faculty of Medicine, Brain Research Center, University of British Columbia, Vancouver, British Columbia, Canada
Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia
Public Health Stream, Hunter Medical Research Institute, New Lambton, New South Wales, Australia
Broad Institute, Cambridge, MA, USA
Framingham Heart Study, Framingham, MA, USA
Department of Neurology, Austin Health, Heidelberg, Victoria, Australia
Stroke Division, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Heidelberg, Victoria, Australia
Estonian Genome Center, University of Tartu, Tartu, Estonia
Department of Neurology, Massachusetts General Hospital (MGH), Harvard Medical School, Boston, MA, USA
Department of Neurology, Caen University Hospital, Caen, France
Department of Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA
Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA
University of Caen Normandy, Caen, France
IBE, Faculty of Medicine, LMU Munich, Munich, Germany
THL-National Institute for Health and Welfare, Helsinki, Finland
FIMM-Institute for Molecular Medicine Finland, Helsinki, Finland
Division of Health and Social Care Research, King's College London, London, UK
Clinical Gene Networks AB, Stockholm, Sweden
National Institute for Health Research Comprehensive Biomedical Research Centre, Guy's & St. Thomas' NHS Foundation Trust and King's College London, London, UK
IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain
Department of Neurology, IMIM-Hospital del Mar, and Universitat Autònoma de Barcelona, Barceloina, Spain
MEB, Karolinska Institutet, Stockholm, Sweden
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany
Department of Medicine I, Ludwig-Maximilians-Universität, Munich, Germany
Department of Cardiac Surgery, Tartu University Hospital, Tartu, Estonia
Department of Pathophysiology, Institute of Biomedicine and Translation Medicine, University of Tartu, Tartu, Estonia
Center for Medical Systems Biology, Leiden, the Netherlands
Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands
Department of Public Health, Bordeaux University Hospital, Bordeaux, France
INSERM, U1219, Bordeaux, France
Department of Neurology, Institute for Neurodegenerative Disease, Bordeaux University Hospital, Bordeaux, France
Sahlgrenska University Hospital, Gothenburg, Sweden
Department of Clinical Neurosciences/Neurology, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
Cardiovascular Health Research Unit, Departments of Biostatistics and Medicine, University of Washington, Seattle, WA, USA
Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK
Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK
Brain Center Rudolf Magnus, Department of Neurology, University Medical Center Utrecht, Utrecht, the Netherlands
Clinical Research Facility, Department of Medicine, NUI Galway, Galway, Ireland
Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada
Department of Neurology and Rehabilitation Medicine, Skåne University Hospital, Lund, Sweden
Department of Clinical Sciences Lund, Neurology, Lund University, Lund, Sweden
Northern Institute for Cancer Research, Newcastle University, Newcastle, UK
SGDP Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK
Departments of Medicine, Pediatrics and Population Health Science, University of Mississippi Medical Center, Jackson, MS, USA
Department of Medical and Molecular Genetics, King's College London, London, UK
VIB Center for Brain & Disease Research, University Hospitals Leuven, Department of Neurology, Leuven, Belgium
Department of Neurosciences, Experimental Neurology, KU Leuven-University of Leuven, Leuven, Belgium
FIMM-Institute for Molecular Medicine Finland, Helsinki, Finland
National Institute for Health and Welfare, Helsinki, Finland
Faculty of Medicine, University of Iceland, Reykjavik, Iceland
Icelandic Heart Association Research Institute, Kopavogur, Iceland
Neurorehabilitation Unit, University of Basel and University Center for Medicine of Aging and Rehabilitation Basel, Felix Platter Hospital, Basel, Switzerland
Department of Neurology and Stroke Center, Basel University Hospital, Basel, Switzerland
Stroke Pharmacogenomics and Genetics, Fundacio Docència i Recerca MutuaTerrassa, Terrassa, Spain
Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA
Neurovascular Research Laboratory, Vall d'Hebron Institut of Research, Neurology and Medicine Departments-Universitat Autònoma de Barcelona, Vall d'Hebrón Hospital, Barcelona, Spain
National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK
MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
Centre Hospitalier Université Lille, Epidemiology and Public Health Department, Lille, France
INSERM, Institut Pasteur de Lille, LabEx DISTALZ-UMR1167, Risk Factors and Molecular Determinants of Aging-Related Diseases, Université Lille, Lille, France
Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands
Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands
Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan
Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan
Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
Department of Psychiatry, Hope Center Program on Protein Aggregation and Neurodegeneration (HPAN), Washington University School of Medicine, St. Louis, MO, USA
Department of Neurology, Institute for Neurodegenerative Disease, Bordeaux University Hospital, Bordeaux, France
Stroke Research Group, Division of Clinical Neurosciences, University of Cambridge, Cambridge, UK
NIHR Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK
Wellcome Trust Centre for Human Genetics, Oxford, UK
Genetic and Genomic Epidemiology Unit, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
Integrated Cardio Metabolic Centre, Department of Medicine, Karolinska Institutet, Karolinska Universitetssjukhuset, Huddinge, Sweden
Department of Pathophysiology, Institute of Biomedicine and Translation Medicine, Biomeedikum, University of Tartu, Tartu, Estonia
Department of Medical Research, Bærum Hospital, Vestre Viken Hospital Trust, Gjettum, Norway
Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA
Department of Genetics, University of North Carolina, Chapel Hill, NC, USA
National Heart, Lung and Blood Research Institute, Division of Intramural Research, Population Sciences Branch, Framingham, MA, USA
Department of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology Icahn School of Medicine at Mount Sinai, New York, NY, USA
Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA
Department of Neurology, Mayo Clinic Rochester, Rochester, MN, USA
Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden
Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA
Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, San Antonio, TX, USA
Oklahoma Center for Neuroscience, Oklahoma City, OK, USA
Department of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
Beth Israel Deaconess Medical Center, Boston, MA, USA
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Boston University School of Public Health, Boston, MA, USA
Issue Date: 2018
EDate: 2018
Citation: Nature genetics 2018; 50(4): 524-537
Abstract: Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown. We conducted a multiancestry genome-wide-association meta-analysis in 521,612 individuals (67,162 cases and 454,450 controls) and discovered 22 new stroke risk loci, bringing the total to 32. We further found shared genetic variation with related vascular traits, including blood pressure, cardiac traits, and venous thromboembolism, at individual loci (n = 18), and using genetic risk scores and linkage-disequilibrium-score regression. Several loci exhibited distinct association and pleiotropy patterns for etiological stroke subtypes. Eleven new susceptibility loci indicate mechanisms not previously implicated in stroke pathophysiology, with prioritization of risk variants and genes accomplished through bioinformatics analyses using extensive functional datasets. Stroke risk loci were significantly enriched in drug targets for antithrombotic therapy.
URI: http://ahro.austin.org.au/austinjspui/handle/1/20814
DOI: 10.1038/s41588-018-0058-3
ORCID: 0000-0001-6624-8621
0000-0002-0311-8472
0000-0003-3223-885X
0000-0001-6888-1404
0000-0003-3687-2508
0000-0002-0473-0241
0000-0001-9088-234X
0000-0002-9501-600X
0000-0002-0276-2899
0000-0001-8081-428X
0000-0001-5894-0351
0000-0002-4787-8959
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0000-0001-5165-4408
0000-0002-8249-8476
0000-0002-9267-7988
0000-0002-7315-7899
0000-0002-2502-3669
0000-0003-2749-1279
0000-0002-3658-1375
0000-0002-7892-8808
0000-0002-8586-5614
0000-0002-8141-0284
0000-0001-9084-7800
0000-0002-6141-4712
0000-0001-5267-6756
0000-0002-2067-0533
0000-0002-2713-686X
0000-0002-7511-5684
0000-0003-3185-5661
0000-0002-7531-2354
0000-0001-6193-020X
0000-0001-8748-5597
0000-0002-0654-387X
0000-0003-3687-2508
0000-0003-0372-8585
0000-0002-7315-7899
0000-0002-2502-3669
0000-0002-6614-8417
PubMed URL: 29531354
Type: Journal Article
Meta-Analysis
Appears in Collections:Journal articles

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