Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/20764
Title: Insulin resistance is associated with reductions in specific cognitive domains and increases in CSF tau in cognitively normal adults.
Authors: Laws, Simon M;Gaskin, Scott;Woodfield, Amy;Srikanth, Velandai;Bruce, David;Fraser, Paul E;Porter, Tenielle;Newsholme, Philip;Wijesekara, Nadeeja;Burnham, Samantha;Doré, Vincent;Li, Qiao-Xin;Maruff, Paul;Masters, Colin L;Rainey-Smith, Stephanie;Rowe, Christopher C;Salvado, Olivier;Villemagne, Victor L;Martins, Ralph N;Verdile, Giuseppe
Affiliation: Cooperative Research Centre for Mental Health, Melbourne, Australia
School of Biomedical Sciences, Faculty of Health Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, Western Australia, Australia
Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, New South Wales, Australia
Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, VIC, Australia
The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia
Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia
CogState Ltd., Melbourne, Victoria, Australia
eHealth, CSIRO Health and Biosecurity, Herston, QLD, Australia
Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, VIC, Australia
eHealth, CSIRO Health and Biosecurity, Parkville, Vic, Australia
Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada
Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
Collaborative Genomics Group, Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia
School of Biomedical Sciences, Faculty of Health Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, Western Australia, Australia
Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia
Peninsula Medical School, Monash University, Melbourne, Australia
School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
Collaborative Genomics Group, Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia
School of Biomedical Sciences, Faculty of Health Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, Western Australia, Australia
Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada
The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia
Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia
eHealth, CSIRO Health and Biosecurity, Herston, QLD, Australia
Issue Date: 29-Aug-2017
EDate: 2017-08-29
Citation: Scientific reports 2017; 7(1): 9766
Abstract: Growing evidence supports the hypothesis that type 2 diabetes (T2D) increases the risk of developing dementia. Experimental evidence from mouse models demonstrates that the induction of T2D/insulin resistance (IR) can promote the accumulation of Alzheimer's disease (AD) pathological features. However, the association of T2D with pathological and clinical phenotypes in is unclear. Here we investigate the relationship of indices of IR (HOMA-IR) and pancreatic β-cell function (HOMA-B) with cognitive performance across several domains (Verbal/Visual Episodic Memory, Executive Function, Language and a measure of Global cognition) and AD biomarkers (CSF Aβ42, T-tau/P-tau, hippocampal volume and neocortical Aβ-amyloid burden). We reveal that HOMA-IR (p < 0.001) incrementally increases across diagnostic groups, becoming significantly elevated in the AD group compared with cognitively normal (CN) adults. In CN adults, higher HOMA-IR was associated with poorer performance on measures of verbal episodic memory (p = 0.010), executive function (p = 0.046) and global cognition (p = 0.007), as well as with higher CSF T-tau (p = 0.008) and P-tau (p = 0.014) levels. No association was observed with CSF Aβ or imaging modalities. Together our data suggest that IR may contribute to reduced cognitive performance and the accumulation of CSF tau biomarkers in cognitively normal adults.
URI: http://ahro.austin.org.au/austinjspui/handle/1/20764
DOI: 10.1038/s41598-017-09577-4
ORCID: 0000-0002-4355-7082
0000-0003-3910-2453
PubMed URL: 28852028
Type: Journal Article
Research Support, Non-U.S. Gov't
Appears in Collections:Journal articles

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