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Title: Changes in Soluble Tumour Necrosis Factor Receptor type 1 levels and early renal function decline in patients with diabetes.
Authors: MacIsaac, Richard J;Farag, Matthew;Obeyesekere, Varuni;Clarke, Michele V;Boston, Ray;Ward, Glenn M;Jerums, George;Ekinci, Elif I
Affiliation: Department of Medicine, University of Melbourne, Victoria, Australia
Department of Endocrinology & Diabetes, St Vincent's Hospital Melbourne
Clinical Chemistry, St Vincent's Hospital Melbourne
Department of Endocrinology & Diabetes, St Vincent's Hospital Melbourne..
Endocrine Centre, Austin Health, Heidelberg, Victoria, Australia
Menzies School of Health Sciences
Issue Date: 15-Apr-2019
EDate: 2019-04-15
Citation: Journal of diabetes investigation 2019; online first: 15 April
Abstract: The relationship between serial changes in soluble tumour necrosis factor receptor type 1 (TNFR1) levels and an early decline in estimated glomerular filtration rate (eGFR) decline remains to be defined. We found that in patients with an early decline in renal function (n=30), soluble TNFR1 values increased (2595±683 vs 3596±1203 pg/mL, p<0.001) as eGFR decreased (89±1 vs 51±2 mL/min/1.73m2 , p<0.001) over an eight year period. In contrast, there were no significant changes in soluble TNFR1 levels in patients with stable renal function (n=17). In a multi-level mixed effects regression model, changes in soluble TNFR1 levels were found to be independently associated with eGFR decline (Z=-4.31, p<0.001). An early decline in eGFR is associated with an increase in soluble TNFR levels; however the factors driving this increase and the possible pathological role that sTNFR1 plays in progressive DKD remains to be determined. This article is protected by copyright. All rights reserved.
DOI: 10.1111/jdi.13061
ORCID: 0000-0003-2372-395X
PubMed URL: 30989829
Type: Journal Article
Subjects: Diabetic kidney disease
Appears in Collections:Journal articles

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