Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/20640
Title: Agomelatine for depression: expanding the horizons?
Authors: Norman, Trevor R;Olver, James S
Affiliation: Department of Psychiatry, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia
Issue Date: Apr-2019
EDate: 2019
Citation: Expert opinion on pharmacotherapy 2019; 20(6): 647-656
Abstract: Agomelatine is an antidepressant with unique pharmacological actions; it is both a melatonin agonist and selective serotonin antagonist. Both actions combined are necessary for antidepressant efficacy. Effects on melatonin receptors enable resynchronisation of disrupted circadian rhythms with beneficial effects on sleep patterns. Areas covered: The issue of use of an antidepressant for depression co-morbid with somatic disorders is covered by the authors. A review of the literature from 2000 to August 2018 was undertaken using Scopus and Web of Science with the key words: agomelatine, depression, medical illness. Depression in Parkinson's disease, cardiovascular illness and type II diabetes is reviewed with evidence of efficacy. Bipolar depression and seasonal affective disorder may also react favourably. Agomelatine may have specific efficacy on symptoms of anhedonia. Expert opinion: Despite approval in some major jurisdictions, the drug has failed to gain registration in the United States. A defining issue may be questions about longer term efficacy: unequivocal effectiveness in placebo-controlled relapse prevention studies has not always been demonstrated. Continuation studies suggest maintenance of clinical responsiveness. A major disadvantage of the drug is its' potential hepatotoxicity and the need for repeated clinical laboratory tests.
URI: http://ahro.austin.org.au/austinjspui/handle/1/20640
DOI: 10.1080/14656566.2019.1574747
ORCID: 0000-0003-2903-7096
PubMed URL: 30759026
Type: Journal Article
Review
Subjects: Agomelatine
anhedonia
depression
elderly
functional outcome
somatic disorders
Appears in Collections:Journal articles

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