Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/20443
Title: Searching for the link; mechanisms underlying liver regeneration and recurrence of colorectal liver metastasis post partial hepatectomy.
Authors: Riddiough, Georgina E;Fifis, Theodora;Muralidharan, Vijayaragavan;Perini, Marcos V;Christophi, Christopher
Affiliation: Department of Surgery, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia
Issue Date: 3-Mar-2019
EDate: 2019
Citation: Journal of gastroenterology and hepatology 2019; online first: 3 March
Abstract: Despite excellent treatment of primary colorectal cancer (CRC) the majority of deaths occur as a result of metastasis to the liver. Recent population studies have estimated that one quarter of patients with CRC will incur synchronous or metachronous colorectal liver metastasis (CRLM). However, only one quarter of these patients will be eligible for potentially curative resection. Tumour recurrence occurs in reportedly 60% of patients undergoing hepatic resection and the majority of intrahepatic recurrence occurs within the first 6 months of surgery. The livers innate ability to restore its homeostatic size and volume facilitates major hepatic resection which currently offers the only chance of cure to patients with extensive hepatic metastases. Experimental and clinical evidence supports the notion that following partial hepatectomy liver regeneration (LR) paradoxically drives tumour progression and increases the risk of recurrence. It is becoming increasingly clear that the processes which drive liver organogenesis, regeneration and tumour progression are inextricably linked. This presents a major hurdle in the management of CRLM and other hepatic malignancies because therapies that reduce the risk of recurrence without hampering LR are sought. The processes and pathways underlying these phenomena are multiple, complex and cross-communicate. In this review we will summarise the common mechanisms contributing to both LR and tumour recurrence.
URI: http://ahro.austin.org.au/austinjspui/handle/1/20443
DOI: 10.1111/jgh.14644
ORCID: 0000-0001-8247-8937
PubMed URL: 30828863
Type: Journal Article
Review
Subjects: colorectal liver metastasis
hepatectomy
liver regeneration
recurrence
Appears in Collections:Journal articles

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