Please use this identifier to cite or link to this item:
|Title:||Prevalence and clinical implications of chronic rhinosinusitis in people with bronchiectasis: a systematic review.|
|Authors:||Handley, Emma;Nicolson, Caroline H;Hew, Mark;Lee, Annemarie L|
|Affiliation:||Department of Physiotherapy, School of Primary and Allied Health Care, Monash University, McMahons Road, Frankston, 3199|
Institute for Breathing and Sleep, Austin Health, Heidelberg, Victoria, Australia
Alfred Health Hospital Admission Risk Program - Pulmonary Rehabilitation, Caulfield Hospital, Kooyong Road, Caulfield
Physiotherapy, Rehabilitation, Nutrition and Sport, La Trobe University, Plenty Road and Kingsbury Drive, Bundoora, 3086
Department of Allergy, Immunology and Respiratory Medicine, Alfred Health, Commercial Road, Melbourne, 3004
|Citation:||The journal of allergy and clinical immunology. In practice 2019; online first: 2 March|
|Abstract:||Chronic rhinosinusitis (CRS) is an extrapulmonary manifestation in some individuals with bronchiectasis, but the prevalence of CRS in this population and its clinical impact has not been systematically reviewed. To systematically review the prevalence of CRS in bronchiectasis and identify its clinical implications. Four databases were searched from inception to August 2018 for studies reporting prevalence and/or clinical impact of CRS in individuals with bronchiectasis. Clinical outcomes included health-related quality of life (HRQOL), severity of bronchiectasis, lung function, clinical and psychological symptoms, exacerbation frequency and health care utilisation. Two independent reviewers rated the quality of evidence using the risk of bias for prevalence trials tool. Of 80 studies identified, eight studies with 797 participants (all adults) were included. Mean FEV1 % predicted was 77.7%. Overall, five studies were classed as low risk of bias and three were of moderate risk of bias. The pooled prevalence of clinical and/or radiological CRS was 62% (95% CI 50% to 74%). CRS was associated with a greater degree of bronchiectasis severity, poorer HRQOL, reduction in smell detection, elevated levels of inflammatory markers and reduced time to first exacerbation. However, the association with airflow obstruction was inconsistent and there was no impact on anxiety or depression. CRS is present in 62% of adults with bronchiectasis. Its presence is associated with poorer HRQOL, greater degree of disease severity and more extensive radiological bronchiectasis.|
Health-related quality of life
|Appears in Collections:||Journal articles|
Files in This Item:
There are no files associated with this item.
Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.