Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/20437
Full metadata record
DC FieldValueLanguage
dc.contributor.authorWong, Anselm-
dc.contributor.authorNejad, C-
dc.contributor.authorGantier, M-
dc.contributor.authorChoy, K W-
dc.contributor.authorDoery, James-
dc.contributor.authorGraudins, A-
dc.date2019-03-06-
dc.date.accessioned2019-03-14T22:35:09Z-
dc.date.available2019-03-14T22:35:09Z-
dc.date.issued2019-03-06-
dc.identifier.citationHuman & experimental toxicology 2019: 960327119833740-
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/20437-
dc.description.abstractParacetamol overdose is common and microRNA (miR)-122 expression is increased with liver injury. We aimed to measure miR-122 in the setting of an abbreviated paracetamol overdose treatment regimen. We compared miRNA expression in patients treated for paracetamol poisoning with an abbreviated 12-h intravenous acetylcysteine regimen (200 mg/kg over 4 h, 50 mg/kg over 8 h) or a 20-h regimen (200 mg/kg over 4 h, 100 mg/kg over 16 h) (NACSTOP trial). miR-122 expression is increased (decreased cycle threshold (Ct) values) with paracetamol liver injury. We assessed miR-122 expression in patients receiving the two acetylcysteine regimens and in a separate group with acute liver injury (ALI). We examined 121 blood samples in 38 patients. After 20 h of acetylcysteine, median alanine transaminase (ALT) was 12 U/L (18, 14) versus 16 U/L (11, 21) ( p = 0.17) and median miR-122 Ct was 30.1 (interquartile range (IQR): 28.9, 33.3) versus 31.4 (28.9, 33.9) ( p = 0.7) in the NACSTOP abbreviated and control groups, respectively. Median normalized miR-122 Ct after 20 h of acetylcysteine was 2.2 (IQR 1.9, 6.4), 1.1 (0.7, 2.9), 63.9 (2.5, 168), 123.2 (40.9, 207.8) in the NACSTOP-abbreviated, NACSTOP-control, ALI and hepatotoxicity groups, respectively. There was no significant difference in ALT or miRNA between NACSTOP treatment groups and no signal of increased liver injury from an abbreviated 12-h acetylcysteine regimen. These findings suggest that an abbreviated acetylcysteine regimen in low-risk patients who have overdosed on paracetamol is safe. Further study is required to validate this finding utilizing miRNA as a comparative biomarker.-
dc.language.isoeng-
dc.subjectAcetaminophen-
dc.subjectNAC-
dc.subjectbiomarkers-
dc.subjecthepatotoxicity-
dc.titleMicroRNA from a 12-h versus 20-h acetylcysteine infusion for paracetamol overdose.-
dc.typeJournal Article-
dc.identifier.journaltitleHuman & experimental toxicology-
dc.identifier.affiliationAustin Toxicology Service, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationMonash Toxicology Unit and Emergency Medicine Service, Monash Health, Victoria, Australiaen
dc.identifier.affiliationDepartment of Molecular and Translational Science, Monash University, Clayton, Victoria, Australiaen
dc.identifier.affiliationCentre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Monash University, Clayton, Victoria, Australiaen
dc.identifier.affiliationDepartment of Medicine, Clinical Sciences at Monash Health, Monash University, Victoria, Australiaen
dc.identifier.affiliationMonash Pathology Department, Monash Health, Victoria, Australiaen
dc.identifier.affiliationDepartment of Emergency Medicine, Austin Health, Heidelberg, Victoria, Australia-
dc.identifier.doi10.1177/0960327119833740-
dc.identifier.orcid0000-0002-6817-7289-
dc.identifier.pubmedid30838890-
Appears in Collections:Journal articles

Files in This Item:
There are no files associated with this item.


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.