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dc.contributor.authorAbadier, Monica-
dc.contributor.authorWong, Anselm-
dc.contributor.authorStathakis, Paul-
dc.contributor.authorSingsit, John-
dc.contributor.authorPillay, Melanie-
dc.contributor.authorGraudins, Andis-
dc.identifier.citationClinical toxicology (Philadelphia, Pa.) 2019; online first: 11 March-
dc.description.abstractLimited data exist regarding paracetamol metabolism after overdose in the neonate. We report a case of repeated supratherapeutic overdose in a neonate with paracetamol metabolite concentrations. A 10-day-old male neonate presented to hospital after repeated supratherapeutic dosing of paracetamol. Paracetamol concentration 19.5 h post-last dose was 381 μmol/L and 236 μmol/L, 9 h later. Initial alanine aminotransferase (ALT) was normal (18 IU/L) and total bilirubin was 262 μmol/L (N < 300). Acetylcysteine infusion was commenced and ceased 27 h later, when serum paracetamol was undetectable and alanine aminotransferase remained normal. Initial paracetamol elimination half-life was 14.5 h. Analysis of serum paracetamol metabolites showed paracetamol-glucuronide was the major metabolite on presentation (64%). After acetylcysteine was commenced, paracetamol concentration fell, serum bilirubin increased, and paracetamol-sulfate represented a larger proportion of total metabolites (72%). Notably, paracetamol cytochrome (CYP450), cysteine- and mercapturate-conjugates, represented 21% of total measured metabolites on presentation. Repeated supratherapeutic ingestion of paracetamol in the neonate was associated with prolonged elimination half-life. Of note, this was in the presence of unconjugated hyperbilirubinaemia. CYP450 metabolism of paracetamol did not appear to be reduced in this neonate when compared to paracetamol metabolite ratios in older age groups.-
dc.subjectGut and hepatotoxicity-
dc.titleA case of accidental neonatal paracetamol overdose with prolonged half-life and measured metabolites.-
dc.typeJournal Article-
dc.identifier.journaltitleClinical toxicology (Philadelphia, Pa.)-
dc.identifier.affiliationDepartment of Paediatrics, Dandenong Hospital, Monash Health, Victoria, Australiaen
dc.identifier.affiliationMonash Toxicology Unit and Emergency Medicine Service, Monash Health, Victoria, Australiaen
dc.identifier.affiliationSEALS Laboratory, Prince of Wales Hospital, Sydney, Australiaen
dc.identifier.affiliationDepartment of Medicine and Radiology, Centre for Integrated Clinical Care, Melbourne Medical School, University of Melbourne, Melbourne, Australiaen
dc.identifier.affiliationAustin Toxicology Service, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationDepartment of Medicine, School of Clinical Sciences, Monash University, Victoria, Australiaen
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