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dc.contributor.authorPorter, Tenielle-
dc.contributor.authorBurnham, Samantha C-
dc.contributor.authorMilicic, Lidija-
dc.contributor.authorSavage, Greg-
dc.contributor.authorMaruff, Paul-
dc.contributor.authorLim, Yen Ying-
dc.contributor.authorAmes, David-
dc.contributor.authorMasters, Colin L-
dc.contributor.authorMartins, Ralph N-
dc.contributor.authorRainey-Smith, Stephanie R-
dc.contributor.authorRowe, Christopher C-
dc.contributor.authorSalvado, Olivier-
dc.contributor.authorGroth, David-
dc.contributor.authorVerdile, Giuseppe-
dc.contributor.authorVillemagne, Victor L-
dc.contributor.authorLaws, Simon M-
dc.identifier.citationNeurobiology of aging 2019; 76: 162-165-
dc.description.abstractThe longevity gene Klotho (KL), specifically the functional KL-VS variant, has previously been associated with cognition and rates of cognitive decline. This study aimed to determine whether KL-VS associations with cognition were observable in preclinical Alzheimer's disease (AD). The study also aimed to determine whether there was a combined influence of KL-VS, neocortical amyloid-β (Aβ) burden, and carriage of the apolipoprotein E (APOE) ε4 allele on cognitive decline. This study involved 581 Aβ-imaged, cognitively normal older adults, enrolled in the Australian Imaging, Biomarkers and Lifestyle Study of Aging. Linear mixed effects models revealed no significant associations between KL-VS and cognitive decline independently or in combination with Aβ burden and APOE ε4 genotype. Overall, previous associations reported between KL-VS and cognitive decline are not observed at the preclinical stages of AD. Furthermore, the results do not support the hypothesis that KL-VS has a modifying effect on Aβ burden and APOE ε4-driven cognitive decline in preclinical AD.-
dc.subjectAlzheimer's disease-
dc.subjectEpisodic memory-
dc.titleKlotho allele status is not associated with Aβ and APOE ε4-related cognitive decline in preclinical Alzheimer's disease.-
dc.typeJournal Article-
dc.identifier.journaltitleNeurobiology of aging-
dc.identifier.affiliationDepartment of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationNational Ageing Research Institute, Parkville, Victoria, Australiaen
dc.identifier.affiliationDepartment of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationSchool of Pharmacy and Biomedical Sciences, Faculty of Health Sciences, Curtin Health Innovation Research Institute, Curtin University, Bentley, Western Australia, Australiaen
dc.identifier.affiliationCSIRO Health and Biosecurity/Australian e-Health Research Centre, Herston, Queensland, Australiaen
dc.identifier.affiliationCentre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australiaen
dc.identifier.affiliationThe Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australiaen
dc.identifier.affiliationDepartment of Psychology, ARC Centre of Excellence in Cognition and its Disorders, Macquarie University, North Ryde, NSW, Australiaen
dc.identifier.affiliationCollaborative Genomics Group, Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australiaen
dc.identifier.affiliationCooperative Research Centre for Mental Health, Carlton South, Victoria, Australiaen
dc.identifier.affiliationCSIRO Health and Biosecurity, Parkville, Victoria, Australiaen
dc.identifier.affiliationCogState Ltd., Melbourne, Victoria, Australiaen
dc.identifier.affiliationAcademic Unit for Psychiatry of Old Age, St. Vincent's Health, The University of Melbourne, Kew, Victoria, Australiaen
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