Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/20343
Title: Klotho allele status is not associated with Aβ and APOE ε4-related cognitive decline in preclinical Alzheimer's disease.
Authors: Porter, Tenielle;Burnham, Samantha C;Milicic, Lidija;Savage, Greg;Maruff, Paul;Lim, Yen Ying;Ames, David;Masters, Colin L;Martins, Ralph N;Rainey-Smith, Stephanie;Rowe, Christopher C;Salvado, Olivier;Groth, David;Verdile, Giuseppe;Villemagne, Victor L;Laws, Simon M
Affiliation: Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia
National Ageing Research Institute, Parkville, Victoria, Australia
Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australia
School of Pharmacy and Biomedical Sciences, Faculty of Health Sciences, Curtin Health Innovation Research Institute, Curtin University, Bentley, Western Australia, Australia
CSIRO Health and Biosecurity/Australian e-Health Research Centre, Herston, Queensland, Australia
Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia
The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia
Department of Psychology, ARC Centre of Excellence in Cognition and its Disorders, Macquarie University, North Ryde, NSW, Australia
Collaborative Genomics Group, Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia
Cooperative Research Centre for Mental Health, Carlton South, Victoria, Australia
CSIRO Health and Biosecurity, Parkville, Victoria, Australia
CogState Ltd., Melbourne, Victoria, Australia
Academic Unit for Psychiatry of Old Age, St. Vincent's Health, The University of Melbourne, Kew, Victoria, Australia
Issue Date: Apr-2019
EDate: 2019-01-06
Citation: Neurobiology of aging 2019; 76: 162-165
Abstract: The longevity gene Klotho (KL), specifically the functional KL-VS variant, has previously been associated with cognition and rates of cognitive decline. This study aimed to determine whether KL-VS associations with cognition were observable in preclinical Alzheimer's disease (AD). The study also aimed to determine whether there was a combined influence of KL-VS, neocortical amyloid-β (Aβ) burden, and carriage of the apolipoprotein E (APOE) ε4 allele on cognitive decline. This study involved 581 Aβ-imaged, cognitively normal older adults, enrolled in the Australian Imaging, Biomarkers and Lifestyle Study of Aging. Linear mixed effects models revealed no significant associations between KL-VS and cognitive decline independently or in combination with Aβ burden and APOE ε4 genotype. Overall, previous associations reported between KL-VS and cognitive decline are not observed at the preclinical stages of AD. Furthermore, the results do not support the hypothesis that KL-VS has a modifying effect on Aβ burden and APOE ε4-driven cognitive decline in preclinical AD.
URI: http://ahro.austin.org.au/austinjspui/handle/1/20343
DOI: 10.1016/j.neurobiolaging.2018.12.014
ORCID: 0000-0003-3910-2453
PubMed URL: 30716541
Type: Journal Article
Subjects: Alzheimer's disease
Cognition
Episodic memory
KL-VS
Klotho
Preclinical
amyloid-β
Appears in Collections:Journal articles

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