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dc.contributor.authorLeitinger, Emma-
dc.contributor.authorHui, Lisa-
dc.contributor.authorGrigg, Andrew P-
dc.identifier.citationInternal Medicine Journal 2019; online first: 5 February-
dc.description.abstractWhile proton pump inhibitors (PPIs) are widely prescribed as prophylaxis in selected haematology inpatient and outpatients , an informal survey of haematology units around Australia found wide variations in the specific indications for their use. This is consistent with a literature review which showed a paucity of robust evidence to support their use, specifically in chemotherapy-induced mucositis, thrombocytopenia or administration of high dose glucocorticosteroids in the absence of additional risk factors. Overuse is relevant both due to cost perspective emerging evidence of adverse events associated with prolonged PPI administration. A review of prescribing practices at our institution over a 14-month period found that approximately 60% of myeloma, lymphoma and autograft patients received PPI prophylaxis during and beyond chemotherapy without an accepted indication. We encourage institutions to review their PPI prescribing practices with the intent of rationalising their use, and to conduct studies aiming to fill the substantial gaps in our knowledge. This article is protected by copyright. All rights reserved.-
dc.titleIs there a role for proton pump inhibitor prophylaxis in haematology patients?-
dc.typeJournal Article-
dc.identifier.journaltitleInternal Medicine Journal-
dc.identifier.affiliationDepartment of Haematology, Peter MacCallum Cancer Centre, Melbourne, Victoria..-
dc.identifier.affiliationDepartment of Clinical Haematology, Austin Health, Heidelberg, Victoria, Australia-
dc.identifier.affiliationOlivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia-
dc.identifier.affiliationUniversity of Melbourne, Melbourne, Victoria, Australia-
Appears in Collections:Journal articles

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