Please use this identifier to cite or link to this item:
Full metadata record
|dc.contributor.author||Grigg, Andrew P||-|
|dc.identifier.citation||Internal Medicine Journal 2019; online first: 5 February||-|
|dc.description.abstract||While proton pump inhibitors (PPIs) are widely prescribed as prophylaxis in selected haematology inpatient and outpatients , an informal survey of haematology units around Australia found wide variations in the specific indications for their use. This is consistent with a literature review which showed a paucity of robust evidence to support their use, specifically in chemotherapy-induced mucositis, thrombocytopenia or administration of high dose glucocorticosteroids in the absence of additional risk factors. Overuse is relevant both due to cost perspective emerging evidence of adverse events associated with prolonged PPI administration. A review of prescribing practices at our institution over a 14-month period found that approximately 60% of myeloma, lymphoma and autograft patients received PPI prophylaxis during and beyond chemotherapy without an accepted indication. We encourage institutions to review their PPI prescribing practices with the intent of rationalising their use, and to conduct studies aiming to fill the substantial gaps in our knowledge. This article is protected by copyright. All rights reserved.||-|
|dc.title||Is there a role for proton pump inhibitor prophylaxis in haematology patients?||-|
|dc.identifier.journaltitle||Internal Medicine Journal||-|
|dc.identifier.affiliation||Department of Haematology, Peter MacCallum Cancer Centre, Melbourne, Victoria..||-|
|dc.identifier.affiliation||Department of Clinical Haematology, Austin Health, Heidelberg, Victoria, Australia||-|
|dc.identifier.affiliation||Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia||-|
|dc.identifier.affiliation||University of Melbourne, Melbourne, Victoria, Australia||-|
|Appears in Collections:||Journal articles|
Files in This Item:
There are no files associated with this item.
Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.