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|Title:||Classic and Nonclassic Renin-Angiotensin Systems in the Critically Ill.|
|Authors:||Bitker, Laurent;Burrell, Louise M|
|Affiliation:||Department of Intensive Care, Austin Health, Heidelberg, Victoria, Australia|
Department of Surgery, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia
|Citation:||Critical care clinics 2019; 35(2): 213-227|
|Abstract:||Classic and nonclassic renin-angiotensin systems (RAS) are 2 sides of an ubiquitous endocrine/paracrine cascade regulating blood pressure and homeostasis. Angiotensin II and angiotensin-converting enzyme (ACE) levels are associated with severity of disease in the critically ill, and are central to the physiology and the pathogenesis of circulatory shock. Angiotensin (1-7) and ACE2 act as an endogenous counterregulatory arm to the angiotensin II/ACE axis. The tissue-based RAS has paracrine effects dissociated from those of the circulating RAS. Exogenous angiotensin II or ACE2 may improve the outcome of septic shock and acute respiratory distress syndrome, respectively.|
|Subjects:||Acute kidney injury|
Acute respiratory distress syndrome
|Appears in Collections:||Journal articles|
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