Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/20296
Title: Hormonal Therapy in Organ Donors.
Authors: Opdam, Helen I
Affiliation: Department of Intensive Care, Austin Health, Heidelberg, Victoria, Australia
Issue Date: Apr-2019
EDate: 2019-01-24
Citation: Critical care clinics 2019; 35(2): 389-405
Abstract: Optimal supportive treatment of brain dead potential organ donors maximizes donation and transplant outcomes. Brain death is associated with activation of inflammatory pathways and loss of autoregulatory brain functions that may include hypothalamic-pituitary dysfunction. As well as general supportive care, specific treatment to counter the common sequelae of brain death such as hypotension, hypothermia, and diabetes insipidus is required. In addition, the provision of specific hormonal therapy (thyroid hormone, vasopressin, and steroids) has been proposed but is controversial due to lack of high level evidence to support its efficacy.
URI: http://ahro.austin.org.au/austinjspui/handle/1/20296
DOI: 10.1016/j.ccc.2018.11.013
PubMed URL: 30784617
Type: Journal Article
Review
Subjects: Brain death
Donor management
Hormone therapy
Organ donation
Steroids
Thyroid hormone
Transplantation
Vasopressin
Appears in Collections:Journal articles

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