Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/20050
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dc.contributor.authorPhillips, Elizabeth J-
dc.contributor.authorBigliardi, Paul-
dc.contributor.authorBircher, Andreas J-
dc.contributor.authorBroyles, Ana-
dc.contributor.authorChang, Yoon-Seok-
dc.contributor.authorChung, Wen-Hung-
dc.contributor.authorLehloenya, Rannakoe-
dc.contributor.authorMockenhaupt, Maja-
dc.contributor.authorPeter, Jonny-
dc.contributor.authorPirmohamed, Munir-
dc.contributor.authorRoujeau, Jean-Claude-
dc.contributor.authorShear, Neil H-
dc.contributor.authorTanno, Luciana Kase-
dc.contributor.authorTrubiano, Jason-
dc.contributor.authorValluzzi, Rocco-
dc.contributor.authorBarbaud, Annick-
dc.date2018-11-30-
dc.date.accessioned2019-01-02T01:15:11Z-
dc.date.available2019-01-02T01:15:11Z-
dc.date.issued2019-
dc.identifier.citationThe Journal of allergy and clinical immunology 2019; 143(1): 66-73-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/20050-
dc.description.abstractControversies exist with regard to in vivo approaches to delayed immunologically mediated adverse drug reactions, such as exanthem (maculopapular eruption), drug reaction with eosinophilia and systemic symptoms, acute generalized exanthematous pustulosis, Stevens-Johnson syndrome/toxic epidermal necrolysis, and fixed drug eruptions. In particular, widespread differences exist between regions and practice on the availability and use of intradermal and patch testing, the standard drug concentrations used, the use of additional drugs in intradermal and patch testing to help determine cross-reactivity, the timing of testing in relation to the occurrence of the adverse drug reaction, the use of testing in specific phenotypes, and the use of oral challenge in conjunction with delayed intradermal and patch testing to ascertain drug tolerance. It was noted that there have been advances in the science of delayed T cell-mediated reactions that have shed light on immunopathogenesis and provided a mechanism of preprescription screening in the case of HLA-B*57:01 and abacavir hypersensitivity and HLA-B*15:02 and carbamazepine Stevens-Johnson syndrome/toxic epidermal necrolysis in Southeast Asian subjects. Future directions should include the collaboration of large international networks to develop and standardize in vivo diagnostic approaches, such as skin testing and patch testing, combined with ex vivo and in vitro laboratory approaches.-
dc.language.isoeng-
dc.subjectDelayed-
dc.subjectHLA-
dc.subjectStevens-Johnson syndrome/toxic epidermal necrolysis-
dc.subjectacute generalized exanthematous pustulosis-
dc.subjectdrug reaction with eosinophilia and systemic symptoms-
dc.subjectfixed drug eruption-
dc.subjectintradermal-
dc.subjectoral challenge-
dc.subjectpatch-
dc.subjectprick-
dc.titleControversies in drug allergy: Testing for delayed reactions.-
dc.typeJournal Article-
dc.identifier.journaltitleThe Journal of allergy and clinical immunology-
dc.identifier.affiliationInstitute for Immunology and Infectious Diseases, Murdoch, Australiaen
dc.identifier.affiliationCentre for Antibiotic Allergy and Research, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationVanderbilt University Medical Center, Nashville, Tennen
dc.identifier.affiliationDepartment of Dermatology, Dermato-Allergy Division, University of Minnesota, Minneapolis, Minn, USA-
dc.identifier.affiliationCentre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdomen
dc.identifier.affiliationDepartment of Dermatology, Dokumentationszentrum schwerer Hautreaktionen (dZh), Medical Center and Medical Faculty, University of Freiburg, Freiburg, Germanyen
dc.identifier.affiliationNational Centre for Infections in Cancer, Department of Infectious Diseases, Peter MacCallum Cancer Centre, Parkville, Australiaen
dc.identifier.affiliationDepartment of Dermatology, Allergy Unit, University Hospital, University of Basel, Basel, Switzerland-
dc.identifier.affiliationBoston Children's Hospital and Harvard Medical School, Boston, Mass, USA-
dc.identifier.affiliationDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea-
dc.identifier.affiliationDepartment of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Taipei, Linkou and Keelung, Taiwan-
dc.identifier.affiliationDivision of Dermatology and Combined Drug Allergy Clinic, Department of Medicine, University of Cape Town, Cape Town, South Africa-
dc.identifier.affiliationUniversité Paris-Est Créteil, Créteil, France-
dc.identifier.affiliationDivision of Dermatology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada-
dc.identifier.affiliationUniversity Hospital of Montpellier, Montpellier, and Sorbonne Université, INSERM, Paris, France; Hospital Sírio Libanês, São Paulo, Brazil-
dc.identifier.affiliationAllergy Department, Pediatric Hospital Bambino Gesù, Rome, Vatican City, Italy-
dc.identifier.affiliationDermatology and Allergy Department, Tenon Hospital, Medecine Sorbonne University, Paris, France-
dc.identifier.affiliationDepartment of Infectious Diseases, Austin Health, Heidelberg, Victoria, Australia-
dc.identifier.affiliationAssistance publique-hopitaux de Paris, Paris, France-
dc.identifier.doi10.1016/j.jaci.2018.10.030-
dc.identifier.orcid0000-0002-5111-6367-
dc.identifier.pubmedid30573342-
dc.type.austinJournal Article-
dc.type.austinReview-
local.name.researcherTrubiano, Jason-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptInfectious Diseases-
crisitem.author.deptMedicine (University of Melbourne)-
crisitem.author.deptCentre for Antibiotic Allergy and Research-
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