Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/19928
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dc.contributor.authorSee, Emily J-
dc.contributor.authorJayasinghe, Kushani-
dc.contributor.authorGlassford, Neil J-
dc.contributor.authorBailey, Michael-
dc.contributor.authorJohnson, David W-
dc.contributor.authorPolkinghorne, Kevan R-
dc.contributor.authorToussaint, Nigel D-
dc.contributor.authorBellomo, Rinaldo-
dc.date2018-11-22-
dc.date.accessioned2018-12-12T02:57:08Z-
dc.date.available2018-12-12T02:57:08Z-
dc.date.issued2019-
dc.identifier.citationKidney International 2019; 95(1): 160-172-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/19928-
dc.description.abstractReliable estimates of the long-term outcomes of acute kidney injury (AKI) are needed to inform clinical practice and guide allocation of health care resources. This systematic review and meta-analysis aimed to quantify the association between AKI and chronic kidney disease (CKD), end-stage kidney disease (ESKD), and death. Systematic searches were performed through EMBASE, MEDLINE, and grey literature sources to identify cohort studies in hospitalized adults that used standardized definitions for AKI, included a non-exposed comparator, and followed patients for at least 1 year. Risk of bias was assessed by the Newcastle-Ottawa Scale. Random effects meta-analyses were performed to pool risk estimates; subgroup, sensitivity, and meta-regression analyses were used to investigate heterogeneity. Of 4973 citations, 82 studies (comprising 2,017,437 participants) were eligible for inclusion. Common sources of bias included incomplete reporting of outcome data, missing biochemical values, and inadequate adjustment for confounders. Individuals with AKI were at increased risk of new or progressive CKD (HR 2.67, 95% CI 1.99-3.58; 17.76 versus 7.59 cases per 100 person-years), ESKD (HR 4.81, 95% CI 3.04-7.62; 0.47 versus 0.08 cases per 100 person-years), and death (HR 1.80, 95% CI 1.61-2.02; 13.19 versus 7.26 deaths per 100 person-years). A gradient of risk across increasing AKI stages was demonstrated for all outcomes. For mortality, the magnitude of risk was also modified by clinical setting, baseline kidney function, diabetes, and coronary heart disease. These findings establish the poor long-term outcomes of AKI while highlighting the importance of injury severity and clinical setting in the estimation of risk.-
dc.language.isoeng-
dc.subjectacute kidney injury-
dc.subjectchronic kidney disease-
dc.subjectdeath-
dc.subjectend-stage kidney disease-
dc.subjectmajor adverse kidney event-
dc.titleLong-term risk of adverse outcomes after acute kidney injury: a systematic review and meta-analysis of cohort studies using consensus definitions of exposure.-
dc.typeJournal Article-
dc.identifier.journaltitleKidney International-
dc.identifier.affiliationDepartment for Continuing Education, University of Oxford, Oxford, UKen
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Melbourne, Victoria, Australiaen
dc.identifier.affiliationDepartment of Nephrology, The Royal Melbourne Hospital, Parkville, Victoria, Australiaen
dc.identifier.affiliationSchool of Medicine, Monash University, Melbourne, Victoria, Australiaen
dc.identifier.affiliationDepartment of Nephrology, Monash Health, Clayton, Victoria, Australiaen
dc.identifier.affiliationDepartment of Intensive Care, Royal Melbourne Hospital, Parkville, Victoria, Australiaen
dc.identifier.affiliationSchool of Public Health and Preventative Medicine, Monash University, Melbourne, Victoria, Australiaen
dc.identifier.affiliationSchool of Medicine, University of Melbourne, Melbourne, Victoria, Australiaen
dc.identifier.affiliationDepartment of Intensive Care, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationAustralian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Victoria, Australiaen
dc.identifier.affiliationDepartment of Nephrology, Princess Alexandra Hospital, Woolloongabba, Queensland, Australiaen
dc.identifier.affiliationCentre for Kidney Disease Research, University of Queensland, Brisbane, Queensland, Australiaen
dc.identifier.affiliationAustralasian Kidney Trials Network, Brisbane, Queensland, Australiaen
dc.identifier.affiliationTranslational Research Institute, Brisbane, Queensland, Australiaen
dc.identifier.affiliationDepartment of Medicine, Monash University, Melbourne, Victoria, Australiaen
dc.identifier.doi10.1016/j.kint.2018.08.036-
dc.identifier.orcid0000-0002-1650-8939-
dc.identifier.pubmedid30473140-
dc.type.austinJournal Article-
local.name.researcherBellomo, Rinaldo-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptIntensive Care-
crisitem.author.deptIntensive Care-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
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