Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/19870
Title: Renin-angiotensin inhibitors reprogram tumor immune microenvironment: A comprehensive view of the influences on anti-tumor immunity.
Authors: Vallejo-Ardila, Dora L;Fifis, Theodora;Burrell, Louise M;Walsh, Katrina;Christophi, Christopher
Affiliation: Department of Surgery, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia
Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia
Department of Cardiology, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia
Issue Date: 26-Oct-2018
EDate: 2018-10-26
Citation: Oncotarget 2018; 9(84): 35500-35511
Abstract: Renin-angiotensin system inhibitors (RASi) have shown potential anti-tumor effects that may have a significant impact in cancer therapy. The components of the renin-angiotensin system (RAS) including both, conventional and alternative axis, appear to have contradictory effects on tumor biology. The mechanisms by which RASi impair tumor growth extend beyond their function of modulating tumor vasculature. The major focus of this review is to analyze other mechanisms by which RASi reprogram the tumor immune microenvironment. These involve impairing hypoxia and acidosis within the tumor stroma, regulating inflammatory signaling pathways and oxidative stress, modulating the function of the non-cellular components and immune cells, and regulating the cross-talk between kalli krein kinin system and RAS.
URI: http://ahro.austin.org.au/austinjspui/handle/1/19870
DOI: 10.18632/oncotarget.26174
ORCID: 0000-0003-1863-7539
PubMed URL: 30464806
Type: Journal Article
Review
Subjects: anti-tumor immunity
kallikrein kinin system
renin-angiotensin system
tumor microenvironment
Appears in Collections:Journal articles

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