Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/19645
Title: Implications of the diagnostic criteria of idiopathic pulmonary fibrosis in clinical practice: Analysis from the Australian Idiopathic Pulmonary Fibrosis Registry.
Authors: Jo, Helen E;Glaspole, Ian;Goh, Nicole S L;Hopkins, Peter M A;Moodley, Yuben;Reynolds, Paul N;Chapman, Sally;Walters, Eugene Haydn;Zappala, Christopher;Allan, Heather;Macansh, Sacha;Grainge, Christopher;Keir, Gregory J;Hayen, Andrew;Henderson, Douglas;Klebe, Sonja;Heinze, Stefan B;Miller, Anne;Rouse, Hannah C;Duhig, Edwina;Cooper, Wendy A;Mahar, Annabelle M;Ellis, Samantha;McCormack, Samuel R;Ng, Bernard;Godbolt, David B;Corte, Tamera J
Affiliation: Pathology Queensland, The Prince Charles Hospital, Brisbane, QLD, Australia
Department of Anatomical pathology, Flinders Medical Centre, Adelaide, SA, Australia
Department of Radiology, Royal Melbourne Hospital, Adelaide, SA, Australia
Department of Radiology, Royal North Shore Hospital, Sydney, NSW, Australia
Department of Radiology, St Vincent's Hospital, Melbourne, VIC, Australia
Department of Anatomical Pathology, Sullivan Nicolaides Pathology, Brisbane, QLD, Australia
Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, NSW, Australia
Department of Radiology, The Alfred Hospital, Melbourne, VIC, Australia
Department of Radiology, Royal Prince Alfred Hospital, Sydney, NSW, Australia
Department of Allergy and Respiratory Medicine, The Alfred Hospital, Melbourne, VIC, Australia
Department of Respiratory Medicine, Austin Hospital, Melbourne, VIC, Australia
Institute for Breathing and Sleep, Austin Health, Heidelberg, Victoria, Australia
Department of Respiratory Medicine, Royal Prince Alfred Hospital, Sydney, NSW, Australia
Faculty of Medicine, University of Sydney, Sydney, NSW, Australia
National Health and Medical Research Council Centre of Research Excellence in Pulmonary Fibrosis, University of Sydney, Sydney, NSW, Australia
Faculty of Medicine, Monash University, Melbourne, VIC, Australia
School of Medicine, University of Queensland, Brisbane, QLD, Australia
Department of Respiratory Medicine, Fiona Stanley Hospital, Perth, WA, Australia
Department of Respiratory Medicine, Royal Adelaide Hospital, Adelaide, SA, Australia
Department of Medicine, University of Adelaide, Adelaide, SA, Australia
Department of Medicine, University of Tasmania, Hobart, TAS, Australia
Department of Thoracic Medicine, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia
Lung Foundation Australia, Brisbane, QLD, Australia
Department of Respiratory Medicine, John Hunter Hospital, Newcastle, NSW, Australia
Department of Respiratory Medicine, Princess Alexandra Hospital, Brisbane, QLD, Australia
Department of Public Health, University of Technology, Sydney, NSW, Australia
Issue Date: 17-Oct-2018
EDate: 2018
Citation: Respirology (Carlton, Vic.) 2018; online first: 17 October
Abstract: Current guidelines for the diagnosis of idiopathic pulmonary fibrosis (IPF) provide specific criteria for diagnosis in the setting of multidisciplinary discussion (MDD). We evaluate the utility and reproducibility of these diagnostic guidelines, using clinical data from the Australian IPF Registry. All patients enrolled in the registry undergo a diagnostic review whereby international IPF guidelines are applied via a registry MDD. We investigated the clinical applicability of these guidelines with regard to: (i) adherence to guidelines, (ii) Natural history of IPF diagnostic categories and (iii) Concordance for diagnostic features. A total of 417 participants (69% male, 70.6 ± 8.0 years) with a clinical diagnosis of IPF underwent MDD. The 23% of participants who did not meet IPF diagnostic criteria displayed identical disease behaviour to those with confirmed IPF. Honeycombing on radiology was associated with a worse prognosis and this translated into poorer prognosis in the 'definite' IPF group. While there was moderate agreement for IPF diagnostic categories, agreement for specific radiological features, other than honeycombing, was poor. In clinical practice, physicians do not always follow IPF diagnostic guidelines. We demonstrate a cohort of IPF patients who do not meet IPF diagnostic guideline criteria, based largely on their radiology and lack of lung biopsy, but who have outcomes identical to those with IPF.
URI: http://ahro.austin.org.au/austinjspui/handle/1/19645
DOI: 10.1111/resp.13427
ORCID: 0000-0003-1183-2729
0000-0002-5118-2890
0000-0003-2065-4346
0000-0002-0777-1196
0000-0002-6565-9928
0000-0002-7096-9365
PubMed URL: 30328644
Type: Journal Article
Subjects: honeycombing
idiopathic pulmonary fibrosis
multidisciplinary
registry
Appears in Collections:Journal articles

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