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Title: ELF3, ELF5, EHF and SPDEF Transcription Factors in Tissue Homeostasis and Cancer.
Authors: Luk, Ian Y;Reehorst, Camilla M;Mariadason, John M
Affiliation: Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia
School of Cancer Medicine, La Trobe University, Bundoora, Victoria 3086, Australia
Issue Date: 30-Aug-2018
EDate: 2018-08-30
Citation: Molecules (Basel, Switzerland) 2018; 23(9): E2191
Abstract: The epithelium-specific ETS (ESE) transcription factors (ELF3, ELF5, EHF and SPDEF) are defined by their highly conserved ETS DNA binding domain and predominant epithelial-specific expression profile. ESE transcription factors maintain normal cell homeostasis and differentiation of a number of epithelial tissues, and their genetic alteration and deregulated expression has been linked to the progression of several epithelial cancers. Herein we review the normal function of the ESE transcription factors, the mechanisms by which they are dysregulated in cancers, and the current evidence for their role in cancer progression. Finally, we discuss potential therapeutic strategies for targeting or reactivating these factors as a novel means of cancer treatment.
DOI: 10.3390/molecules23092191
ORCID: 0000-0001-9123-7684
PubMed URL: 30200227
Type: Journal Article
Subjects: EHF
transcription factor
Appears in Collections:Journal articles

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