Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/19524
Title: Using routine HbA1c measurements in stroke and the associations of dysglycaemia with stroke outcomes.
Authors: Lew, Jeremy F;Thijs, Vincent N;Churilov, Leonid;Donnan, Geoffrey;Park, Warwick;Robbins, Raymond J;Hart, Graeme K;Bladin, Christopher;Khoo, Kaylyn;Lau, Lik-Hui;Tan, Alanna;Lam, Que T;Johnson, Douglas F;Zajac, Jeffrey D;Ekinci, Elif I
Affiliation: Stroke Division, The Florey Institute of Neuroscience and Mental Health, Melbourne, Vic., Australia
Department of Neurology, Austin Health, Heidelberg, Victoria, Australia
Department of Administrative Informatics, Austin Health, Heidelberg, Victoria, Australia
Department of Intensive Care, Austin Health, Heidelberg, Victoria, Australia
Health and Biomedical Informatics Centre, University of Melbourne, Australia
Department of Neurosciences, Eastern Health, Box Hill Hospital, Box Hill, Vic., Australia
Department of Endocrinology, Austin Health, Heidelberg, Victoria, Australia
Department of Pathology, Austin Health, Heidelberg, Victoria, Australia
Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia
Department of General Medicine, Austin Health, Heidelberg, Victoria, Australia
Issue Date: 18-Aug-2018
EDate: 2018
Citation: Journal of diabetes and its complications 2018; online first: 18 August
Abstract: Diabetes is a major risk factor for stroke. We aimed to investigate the prevalence of diabetes and pre-diabetes within a stroke cohort and examine the association of glycaemia status with mortality and morbidity. Inpatients aged ≥54 who presented with a diagnosis of stroke had a routine HbA1c measurement as part of the Austin Health Diabetes Discovery Initiative. Additional data were attained from hospital databases and Australian Stroke Clinical Registry. Outcomes included diabetes and pre-diabetes prevalence, length of stay, 6-month and in-hospital mortality, 28-day readmission rates, and 3-month modified Rankin scale score. Between July 2013 and December 2015, 610 patients were studied. Of these, 31% had diabetes while 40% had pre-diabetes. Using multivariable regression analyses, the presence of diabetes was associated with higher odds of 6-month mortality (OR = 1.90, p = 0.022) and higher expected length of stay (IRR = 1.29, p = 0.004). Similarly, a higher HbA1c was associated with higher odds of 6-month mortality (OR = 1.27, p = 0.005) and higher expected length of stay (IRR = 1.08, p = 0.010). 71% of this cohort had diabetes or pre-diabetes. Presence of diabetes and higher HbA1c were associated with higher 6-month mortality and length of stay. Further research is necessary to determine if improved glycaemic control may improve stroke outcomes.
URI: http://ahro.austin.org.au/austinjspui/handle/1/19524
DOI: 10.1016/j.jdiacomp.2018.08.013
ORCID: 0000-0003-2372-395X
0000-0002-6614-8417
0000-0001-6324-3403
0000-0002-9807-6606
PubMed URL: 30172697
Type: Journal Article
Subjects: Diabetes mellitus
Electronic Health Records
Hemoglobin A glycosylated
Prevalence
Stroke
Appears in Collections:Journal articles

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