Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/19431
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dc.contributor.authorSalter, Ryan-
dc.contributor.authorBailey, Michael-
dc.contributor.authorBellomo, Rinaldo-
dc.contributor.authorEastwood, Glenn M-
dc.contributor.authorGoodwin, Andrew-
dc.contributor.authorNielsen, Niklas-
dc.contributor.authorPilcher, David-
dc.contributor.authorNichol, Alistair-
dc.contributor.authorSaxena, Manoj-
dc.contributor.authorShehabi, Yahya-
dc.contributor.authorYoung, Paul-
dc.date2018-07-30-
dc.date.accessioned2018-09-17T01:47:08Z-
dc.date.available2018-09-17T01:47:08Z-
dc.date.issued2018-11-
dc.identifier.citationCritical Care Medicine 2018; 46(11): 1722-1730-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/19431-
dc.description.abstractTo evaluate knowledge translation after publication of the target temperature management 33°C versus 36°C after out-of-hospital cardiac arrest trial and associated patient outcomes. Our primary hypothesis was that target temperature management at 36°C was rapidly adopted in Australian and New Zealand ICUs. Secondary hypotheses were that temporal reductions in mortality would be seen and would have accelerated after publication of the target temperature management trial. Retrospective cohort study (January 2005 to December 2016). The Australian and New Zealand Intensive Care Society Centre for Outcome and Resource Evaluation adult patient database containing greater than 2 million admission episodes from 186 Australian and New Zealand ICUs. Sixteen-thousand two-hundred fifty-two adults from 140 hospitals admitted to ICU after out-of-hospital cardiac arrest. The primary exposure of interest was admission before versus after publication of the target temperature management trial. The primary outcome variable to evaluate changes in temperature management was lowest temperature in the first 24 hours in ICU. The primary clinical outcome variable of interest was inhospital mortality. Secondary outcomes included proportion of patients with fever in the first 24 hours in ICU. Mean ± SD lowest temperature in the first 24 hours in ICU in pre- and posttarget temperature management trial patients was 33.80 ± 1.71°C and 34.70 ± 1.39°C, respectively (absolute difference, 0.98°C [99% CI, 0.89-1.06°C]). Inhospital mortality rate decreased by 1.3 (99% CI, -1.8 to -0.9) percentage points per year from January 2005 until December 2013 and increased by 0.6 (99% CI, -1.4 to 2.6) percentage points per year from January 2014 until December 2016 (change in slope 1.9 percentage points per year [99% CI, -0.6 to 4.4]). Fever occurred in 568 (12.8%) of 4,450 pretarget temperature management trial patients and 853 (16.5%) of 5,184 posttarget temperature management trial patients (odds ratio, 1.35 [99% CI, 1.16-1.57]). The average lowest temperature of postcardiac arrest patients in the first 24 hours in ICU rose after publication of the target temperature management trial. This change was associated with an increased frequency of fever not seen in the target temperature management trial.-
dc.language.isoeng-
dc.titleChanges in Temperature Management of Cardiac Arrest Patients Following Publication of the Target Temperature Management Trial.-
dc.typeJournal Article-
dc.identifier.journaltitleCritical Care Medicine-
dc.identifier.affiliationMedical Research Institute of New Zealand, Wellington, New Zealanden
dc.identifier.affiliationIntensive Care Unit, St George Hospital, Sydney, NSW, Australiaen
dc.identifier.affiliationIntensive Care Unit, Monash Medical Centre, Melbourne, Victoria, Australiaen
dc.identifier.affiliationIntensive Care Unit, Wellington Regional Hospital, Wellington, New Zealanden
dc.identifier.affiliationAustralian and New Zealand Intensive Care Research Center, Monash University, Melbourne, Victoria, Australiaen
dc.identifier.affiliationSchool of Medicine, University of Melbourne, Melbourne, Victoria, Australiaen
dc.identifier.affiliationSchool of Clinical Sciences, Monash University, Melbourne, Victoria, Australiaen
dc.identifier.affiliationIntensive Care Unit, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationFaculty of Engineering and Information Technologies, University of Sydney, Sydney, NSW, Australiaen
dc.identifier.affiliationDepartment of Clinical Sciences, Lund University, Lund, Swedenen
dc.identifier.affiliationDepartment of Anesthesiology and Intensive Care, Helsingborg Hospital, Helsingborg, Swedenen
dc.identifier.affiliationIntensive Care Unit, Alfred Hospital, Melbourne, Victoria, Australiaen
dc.identifier.affiliationDivision of Critical Care and Trauma, The Australian and New Zealand Intensive Care Society Centre for Outcome and Resource Evaluation, Melbourne, Victoria, Australiaen
dc.identifier.affiliationUniversity College Dublin-Clinical Research Centre at St Vincent's University Hospital, Dublin, Irelanden
dc.identifier.affiliationDivision of Critical Care and Trauma, George Institute for Global Health, Sydney, NSW, Australiaen
dc.identifier.affiliationSt George Clinical School, University of New South Wales, NSW, Australiaen
dc.identifier.doi10.1097/CCM.0000000000003339-
dc.identifier.orcid0000-0002-1650-8939-
dc.identifier.pubmedid30063490-
dc.type.austinJournal Article-
local.name.researcherBellomo, Rinaldo
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.languageiso639-1en-
crisitem.author.deptIntensive Care-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
crisitem.author.deptIntensive Care-
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