Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/19405
Title: Episodic Memory and Learning Dysfunction Over an 18-Month Period in Preclinical and Prodromal Alzheimer's Disease.
Authors: Baker, Jenalle E;Ying Lim, Yen;Jaeger, Judith;Ames, David;Lautenschlager, Nicola T;Robertson, Joanne;Pietrzak, Robert H;Snyder, Peter J;Villemagne, Victor L;Rowe, Christopher C;Masters, Colin L;Maruff, Paul
Affiliation: Cogstate Ltd., Melbourne, VIC, Australia
Ryan Institute for Neuroscience, University of Rhode Island, Kingston, RI, USA
Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australia
Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia
The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia
Cooperative Research Centre for Mental Health, Carlton, Victoria, Australia
CognitionMetrics, LLC., Wilmington, DE, USA
Albert Einstein College of Medicine, Bronx, NY, USA
National Ageing Research Institute, Parkville, VIC, Australia
Department of Psychiatry, Academic Unit for Psychiatry of Old Age, The University of Melbourne, St. George's Hospital, Kew, VIC, Australia
U.S. Department of Veterans Affairs National Center for Posttraumatic Stress Disorder, Clinical Neurosciences Division, VA Connecticut Healthcare System, West Haven, CT, USA
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
Issue Date: 9-Aug-2018
EDate: 2018
Citation: Journal of Alzheimer's disease : JAD 2018; 65(3): 977-988
Abstract: Recent meta-analyses suggest that episodic memory impairment associated with preclinical Alzheimer's disease (AD) equates to 0.15-0.24 standard deviations below that of cognitively healthy older adults. The current study aimed to characterize impairments in verbal acquisition and recall detectable at a single assessment, and investigate how verbal learning and episodic memory deteriorates in preclinical AD. A verbal list-learning task, the International Shopping List Test (ISLT), was administered multiple times over an 18-month period, to three groups of participants: amyloid-beta negative healthy older adults (Aβ- CN; n = 50); Aβ+ positive healthy older adults (preclinical AD; n = 25); and Aβ+ positive individuals diagnosed with mild cognitive impairment (prodromal AD; n = 22). At baseline, there was no significant difference between the preclinical AD and control groups rate of acquisition, or total and delayed recall, however all indices were impaired in prodromal AD. Performance on ISLT total score improved in the control group over the 18-month period, but showed a moderate magnitude decline in the preclinical AD group (Cohen's d = - 0.63, [- 1.12, - 0.14]) and the prodromal AD group (Cohen's d = - 0.36, [- 0.94, 0.22]). No significant impairment in acquisition associated with preclinical AD was seen at baseline. Individuals with preclinical AD showed a significantly different performance on the ISLT total score over an 18-month period, compared to those without abnormal Aβ. Individuals with prodromal AD showed substantial impairment on the ISLT at baseline and declined to a greater extent over time.
URI: http://ahro.austin.org.au/austinjspui/handle/1/19405
DOI: 10.3233/JAD-180344
ORCID: 0000-0003-3910-2453
PubMed URL: 30103330
Type: Journal Article
Subjects: Alzheimer’s disease
amyloid-β protein
cognitive decline
learning curve
memory and learning tests
mild cognitive impairment
neuropsychology
transfer of learning
Appears in Collections:Journal articles

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