Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/19389
Title: Comparative sensitivity and specificity of imaging modalities in staging bladder cancer prior to radical cystectomy: a systematic review and meta-analysis.
Authors: Crozier, Jack;Papa, Nathan P;Perera, Marlon;Ngo, Brian;Bolton, Damien M;Sengupta, Shomik;Lawrentschuk, Nathan L
Affiliation: Department of Surgery, Austin Health, Heidelberg, Victoria, Australia
The University of Melbourne, Parkville, VIC, Australia
Division of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia
Issue Date: 17-Aug-2018
EDate: 2018-08-17
Citation: World journal of urology 2018; online first: 17 August
Abstract: The detection of lymph node metastases in bladder cancer has a significant impact on treatment decisions. Multiple imaging modalities are available to clinicians including magnetic resonance imaging, computed tomography and positron emission tomography. We aimed to investigate the utility of alternate imaging modalities on pre-cystectomy imaging in bladder cancer for the detection of lymph node metastases. We performed systematic search of Web of Science (including MEDLINE), EMBASE and Cochrane libraries in accordance with the PRISMA statement. Studies comparing lymph node imaging findings with final histopathology were included in our analysis. Sensitivity and specificity data were quantified using patient-based analysis. A true positive was defined as a node-positive patient on imaging and node positive on histopathology. Meta-analysis of studies was performed using a mixed-effects, hierarchical logistic regression model. Our systematic search identified 35 articles suitable for inclusion. MRI and PET have a higher sensitivity than CT while the specificity of all modalities was similar. The summary MRI sensitivity = 0.60 (95% CI 0.44-0.74) and specificity = 0.91 (95% CI 0.82-0.96). Summary PET/CT sensitivity = 0.56 (95% CI 0.49-0.63) and specificity = 0.92 (95% CI 0.86-0.95). Summary CT sensitivity = 0.40 (95% CI 0.33-0.49) and specificity = 0.92 (95% CI 0.86-0.95). MRI and PET/CT provides superior sensitivity compared to CT for detection of positive lymph nodes in bladder cancer prior to cystectomy. There is variability in the accuracy that current imaging modalities achieve across different studies. A number of other factors impact on detection accuracy and these must be considered.
URI: http://ahro.austin.org.au/austinjspui/handle/1/19389
DOI: 10.1007/s00345-018-2439-8
ORCID: 0000-0002-5145-6783
0000-0003-3357-1216
0000-0001-8553-5618
0000-0001-8419-7469
0000-0002-3188-1803
0000-0002-1138-6389
PubMed URL: 30120501
Type: Journal Article
Review
Subjects: Bladder cancer
Computed tomography
Magnetic resonance imaging
Positron emission tomography
Transitional cell carcinoma
Appears in Collections:Journal articles

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