Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/19337
Full metadata record
DC FieldValueLanguage
dc.contributor.authorMegens, Matthew R-
dc.contributor.authorChurilov, Leonid-
dc.contributor.authorThijs, Vincent-
dc.date2017-
dc.date.accessioned2018-09-16T23:53:55Z-
dc.date.available2018-09-16T23:53:55Z-
dc.date.issued2017-12-22-
dc.identifier.citationJournal of the American Heart Association 2017; 6(12): pii: e007558-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/19337-
dc.description.abstractNew-onset atrial fibrillation (NOAF) after coronary artery bypass graft is related to an increased short-term risk of stroke and mortality. We investigated whether the long-term risk of stroke is increased. We performed a systematic review and meta-analysis of studies that included patients who had coronary artery bypass graft and who afterwards developed NOAF during their index admission; these patients did not have previous atrial fibrillation. The primary outcome was risk of stroke at 6 months or more in patients who developed NOAF compared with those who did not. Odds ratios, relative risk, and hazard ratios were considered equivalent; outcomes were pooled on the log-ratio scale using a random-effects model and reported as exponentiated effect-sizes. We included 16 studies, comprising 108 711 participants with a median follow-up period of 2.05 years. Average participant age was 66.8 years, with studies including an average of 74.8% males. There was an increased long-term risk of stroke in the presence of NOAF (unadjusted studies effect-sizes=1.36, 95% confidence interval, 1.12-1.65, P=0.001, adjusted studies effect-sizes=1.25, 95% confidence interval, 1.09-1.42, P=0.001). There was evidence of moderate effect variation because of heterogeneity in studies reporting unadjusted (P=0.021, I2=49.8%) and adjusted data (P=0.081, I2=49.1%), and publication bias in the latter group (Egger's test, P=0.031). Sensitivity analysis on unadjusted data by study quality, design, and surgery did not alter the effect direction. Presence of NOAF in patients post-coronary artery bypass graft is associated with increased long-term risk of stroke compared with patients without NOAF. Further studies may show whether the increased risk is mediated by atrial fibrillation and whether anticoagulation reduces risk.-
dc.language.isoeng-
dc.subjectatrial fibrillation-
dc.subjectcoronary artery bypass surgery-
dc.subjectcoronary artery graft surgery-
dc.subjectmeta‐analysis-
dc.subjectStroke-
dc.subjectsystematic review-
dc.titleNew-Onset Atrial Fibrillation After Coronary Artery Bypass Graft and Long-Term Risk of Stroke: A Meta-Analysis.-
dc.typeJournal Article-
dc.identifier.journaltitleJournal of the American Heart Association-
dc.identifier.affiliationThe Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Heidelberg, Victoria, Australia-
dc.identifier.affiliationSchool of Sciences, RMIT University, Melbourne, Victoria, Australia-
dc.identifier.affiliationDepartment of Neurology, Austin Health, Heidelberg, Victoria, Australia-
dc.identifier.doi10.1161/JAHA.117.007558-
dc.identifier.orcid0000-0002-9807-6606-
dc.identifier.orcid0000-0002-6614-8417-
dc.identifier.pubmedid29273637-
dc.type.austinJournal Article-
dc.type.austinReview-
local.name.researcherChurilov, Leonid
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.languageiso639-1en-
crisitem.author.deptMedicine (University of Melbourne)-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

8
checked on Mar 27, 2024

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.