Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/19321
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dc.contributor.authorDefres, Sylviane-
dc.contributor.authorKeller, Simon S-
dc.contributor.authorDas, Kumar-
dc.contributor.authorVidyasagar, Rishma-
dc.contributor.authorParkes, Laura M-
dc.contributor.authorBurnside, Girvan-
dc.contributor.authorGriffiths, Michael-
dc.contributor.authorKopelman, Michael-
dc.contributor.authorRoberts, Neil-
dc.contributor.authorSolomon, Tom-
dc.date2017-
dc.date.accessioned2018-09-13T00:24:46Z-
dc.date.available2018-09-13T00:24:46Z-
dc.date.issued2017-01-26-
dc.identifier.citationPLoS One 2017; 12(1): e0170215-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/19321-
dc.description.abstractTo assess whether it is feasible to quantify acute change in temporal lobe volume and total oedema volumes in herpes simplex virus (HSV) encephalitis as a preliminary to a trial of corticosteroid therapy. The study analysed serially acquired magnetic resonance images (MRI), of patients with acute HSV encephalitis who had neuroimaging repeated within four weeks of the first scan. We performed volumetric measurements of the left and right temporal lobes and of cerebral oedema visible on T2 weighted Fluid Attenuated Inversion Recovery (FLAIR) images using stereology in conjunction with point counting. Temporal lobe volumes increased on average by 1.6% (standard deviation (SD 11%) in five patients who had not received corticosteroid therapy and decreased in two patients who had received corticosteroids by 8.5%. FLAIR hyperintensity volumes increased by 9% in patients not receiving treatment with corticosteroids and decreased by 29% in the two patients that had received corticosteroids. This study has shown it is feasible to quantify acute change in temporal lobe and total oedema volumes in HSV encephalitis and suggests a potential resolution of swelling in response to corticosteroid therapy. These techniques could be used as part of a randomized control trial to investigate the efficacy of corticosteroids for treating HSV encephalitis in conjunction with assessing clinical outcomes and could be of potential value in helping to predict the clinical outcomes of patients with HSV encephalitis.-
dc.language.isoeng-
dc.titleA Feasibility Study of Quantifying Longitudinal Brain Changes in Herpes Simplex Virus (HSV) Encephalitis Using Magnetic Resonance Imaging (MRI) and Stereology.-
dc.typeJournal Article-
dc.identifier.journaltitlePLoS One-
dc.identifier.affiliationClinical Infection, microbiology and immunology, Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom-
dc.identifier.affiliationTropical and Infectious diseases Unit, Liverpool and Broadgreen University Hospital Trust, Liverpool, United Kingdom-
dc.identifier.affiliationNIHR HPRU in Emerging and Zoonotic Infections, University of Liverpool, Institute of infection and Global Health, Waterhouse Building, Liverpool, United Kingdom-
dc.identifier.affiliationThe Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom-
dc.identifier.affiliationThe Department of Neuroradiology, The Walton Centre NHS Foundation Trust, Liverpool, Liverpool, United Kingdom-
dc.identifier.affiliationThe Florey Institute of Neuroscience and Mental Health, Heidelberg, Victoria, Australia-
dc.identifier.affiliationDepartment of Anatomy and Neuroscience, University of Melbourne, Victoria, Australia-
dc.identifier.affiliationDivision of Neuroscience and Experimental Psychology, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom-
dc.identifier.affiliationThe department of Biostatistics, Institute of translational medicine, University of Liverpool, Liverpool, United Kingdom-
dc.identifier.affiliationAlder Hey Children's NHS Foundation Trust, Liverpool, United Kingdom-
dc.identifier.affiliationInstitute of Psychiatry, Kings College London, London, United Kingdom-
dc.identifier.affiliationMedical Physics and Imaging Science, University of Edinburgh, Edinburgh, United Kingdom-
dc.identifier.doi10.1371/journal.pone.0170215-
dc.identifier.orcid0000-0002-4729-7505-
dc.identifier.orcid0000-0002-1484-4250-
dc.identifier.pubmedid28125598-
dc.type.austinJournal Article-
dc.type.austinRandomized Controlled Trial-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
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