Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/19288
Title: Social Isolation Alters Social and Mating Behavior in the R451C Neuroligin Mouse Model of Autism.
Authors: Burrows, E L;Eastwood, A F;May, C;Kolbe, S C;Hill, T;McLachlan, N M;Churilov, Leonid;Hannan, A J
Affiliation: Florey Institute of Neuroscience and Mental Health, Melbourne Brain Centre, University of Melbourne, Parkville, VIC 3010, Australia
Department of Anatomy and Neuroscience, University of Melbourne, Parkville, VIC 3010, Australia
Psychological Sciences, University of Melbourne, Parkville, VIC 3010, Australia
The Florey Institute of Neuroscience and Mental Health, Heidelberg, Victoria, Australia
Issue Date: 2017
EDate: 2017-01-31
Citation: Neural plasticity 2017; 2017: 8361290
Abstract: Autism spectrum disorder (ASD) is a neurodevelopmental disorder typified by impaired social communication and restrictive and repetitive behaviors. Mice serve as an ideal candidate organism for studying the neural mechanisms that subserve these symptoms. The Neuroligin-3 (NL3) mouse, expressing a R451C mutation discovered in two Swedish brothers with ASD, exhibits impaired social interactions and heightened aggressive behavior towards male mice. Social interactions with female mice have not been characterized and in the present study were assessed in male NL3R451C and WT mice. Mice were housed in social and isolation conditions to test for isolation-induced increases in social interaction. Tests were repeated to investigate potential differences in interaction in naïve and experienced mice. We identified heightened interest in mating and atypical aggressive behavior in NL3R451C mice. NL3R451C mice exhibited normal social interaction with WT females, indicating that abnormal aggressive behavior towards females is not due to altered motivation to engage. Social isolation rearing heightened interest in social behavior in all mice. Isolation housing selectively modulated the response to female pheromones in NL3R451C mice. This study is the first to show altered mating behavior in the NL3R451C mouse and has provided new insights into the aggressive phenotype in this model.
URI: http://ahro.austin.org.au/austinjspui/handle/1/19288
DOI: 10.1155/2017/8361290
ORCID: 0000-0002-6675-4679
0000-0003-4685-1380
0000-0001-7532-8922
0000-0002-9807-6606
PubMed URL: 28255463
Type: Journal Article
Research Support, Non-U.S. Gov't
Appears in Collections:Journal articles

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