Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/19231
Title: Standardized Expression of 18F-NAV4694 and 11C-PiB β-Amyloid PET Results with the Centiloid Scale.
Authors: Rowe, Christopher C;Jones, Gareth;Doré, Vincent;Pejoska, Svetlana;Margison, Laura;Mulligan, Rachel S;Chan, J Gordon;Young, Kenneth;Villemagne, Victor L
Affiliation: Department of Molecular Imaging and Therapy, Austin Health, Heidelberg, Victoria, Australia
Department of Medicine, University of Melbourne, Melbourne, Australia
Australia CSIRO Health and Biosecurity, Brisbane, Australia
The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia
Issue Date: Aug-2016
EDate: 2016-02-16
Citation: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2016; 57(8): 1233-1237
Abstract: A common quantitative output value for PET measures of β-amyloid (Aβ) binding across tracers and methods would allow better comparison of data across sites and application of universal diagnostic and prognostic values. A method has recently been developed that generates a unit of measurement called the centiloid. We applied this method to 2-[2-(18)F-fluoro-6-(methylamino)-3-pyridinyl]-1-benzofuran-5-ol ((18)F-NAV4694) and (11)C-Pittsburgh compound B ((11)C-PiB) Aβ images to derive the scaling factor required to express tracer binding in centiloids. Fifty-five participants, including 10 young controls (33 ± 7 y old), underwent both (11)C-PiB and (18)F-NAV4694 imaging no more than 3 mo apart, with the images acquired 50-70 min after tracer injection. The images were spatially normalized and analyzed using the standard centiloid method and regions (cortex and whole-cerebellum reference) downloaded from the Global Alzheimer Association Interactive Network website. SUV ratios (SUVRs) showed a strong correlation in tracer binding ((18)F-NAV4694 SUVR = 1.09 × (11)C-PiB SUVR - 0.08, R(2) = 0.99). The equation to convert (18)F-NAV4694 to centiloids [100 × ((18)F-NAV4694 SUVR - 1.028)/1.174] was similar to a published equation for (11)C-PiB [100 × ((11)C-PiB SUVR - 1.009)/1.067]. In the young controls, the variance ratio ((18)F-NAV4694 centiloid SD divided by (11)C-PiB centiloid SD) was 0.85. The results for both (11)C-PiB and (18)F-NAV4694 can now be expressed in centiloids, an important step that should allow better clinical and research use of Aβ imaging. The standard centiloid method also showed that (18)F-NAV4694 has slightly higher Aβ binding and lower variance than (11)C-PiB, important properties for detecting early Aβ deposition and change over time.
URI: http://ahro.austin.org.au/austinjspui/handle/1/19231
DOI: 10.2967/jnumed.115.171595
ORCID: 0000-0003-3910-2453
PubMed URL: 26912446
Type: Comparative Study
Journal Article
Subjects: Alzheimer’s disease
amyloid imaging
beta-amyloid
centiloid
standardization
Appears in Collections:Journal articles

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