Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/18765
Title: Estimates of age-related memory decline are inflated by unrecognized Alzheimer's disease.
Authors: Harrington, Karra D;Schembri, Adrian;Lim, Yen Ying;Dang, Christa;Ames, David;Hassenstab, Jason;Laws, Simon M;Rainey-Smith, Stephanie;Robertson, Joanne;Rowe, Christopher C;Sohrabi, Hamid R;Salvado, Olivier;Weinborn, Michael;Villemagne, Victor L;Masters, Colin L;Maruff, Paul
Affiliation: The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia
Cooperative Research Centre for Mental Health, Carlton, Victoria, Australia
CogState Ltd., Melbourne, Victoria, Australia
Department of Obstetrics and Gynaecology, Melbourne Medical School, The University of Melbourne, Parkville, Victoria, Australia
Department of Psychiatry, Academic Unit for Psychiatry of Old Age, The University of Melbourne, Parkville, Victoria, Australia
National Ageing Research Institute, Parkville, Victoria, Australia
Charles F. and Joanne Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA
Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA
Department of Psychological & Brain Sciences, Washington University, St. Louis, MO, USA
Collaborative Genomics Group, Centre of Excellence for Alzheimer's Disease Research and Care, School of Exercise, Biomedical and Health Sciences, Edith Cowan University, Perth, Western Australia, Australia
School of Biomedical Sciences, Faculty of Health Sciences, Curtin Health Innovation Research Institute, Curtin University, Western Australia, Australia
Centre of Excellence for Alzheimer's Disease Research and Care, School of Exercise, Biomedical and Health Sciences, Edith Cowan University, Perth, Western Australia, Australia
Australian Alzheimer's Disease Research Unit, Hollywood Private Hospital, Perth, Western Australia, Australia
Department of Molecular Imaging and Therapy, Austin Health, Heidelberg, Victoria, Australia
Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia
School of Psychiatry and Clinical Neurosciences, University of Western Australia, Nedlands, Western Australia, Australia
CSIRO Health and Biosecurity, The Australian eHealth Research Centre, Brisbane, Queensland, Australia
School of Psychological Science, University of Western Australia, Crawley, Western Australia, Australia
Issue Date: 11-Jun-2018
EDate: 2018-06-11
Citation: Neurobiology of aging 2018; 70: 170-179
Abstract: Cognitive decline is considered an inevitable consequence of aging; however, estimates of cognitive aging may be influenced negatively by undetected preclinical Alzheimer's disease (AD). This study aimed to determine the extent to which estimates of cognitive aging were biased by preclinical AD. Cognitively normal older adults (n = 494) with amyloid-β status determined from positron emission tomography neuroimaging underwent serial neuropsychological assessment at 18-month intervals over 72 months. Estimates of the effects of age on verbal memory, working memory, executive function, and processing speed were derived using linear mixed models. The presence of preclinical AD and clinical progression to mild cognitive impairment or dementia during the study were then added to these models as covariates. Initially, age was associated with decline across all 4 cognitive domains. With the effects of elevated amyloid-β and clinical progression controlled, age was no longer associated with decline in verbal or working memory. However, the magnitude of decline was reduced only slightly for executive function and was unchanged for processing speed. Thus, considered together, the results of the study indicate that undetected preclinical AD negatively biases estimates of age-related cognitive decline for verbal and working memory.
URI: http://ahro.austin.org.au/austinjspui/handle/1/18765
DOI: 10.1016/j.neurobiolaging.2018.06.005
ORCID: 0000-0003-3910-2453
PubMed URL: 30015036
Type: Journal Article
Subjects: Aging
Alzheimer
Amyloid-β
Cognition
Preclinical
Appears in Collections:Journal articles

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