Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/18625
Title: T-box Transcription Factors Combine with the Cytokines TGF-β and IL-15 to Control Tissue-Resident Memory T Cell Fate.
Authors: Mackay, Laura K;Wynne-Jones, Erica;Freestone, David;Pellicci, Daniel G;Mielke, Lisa A;Newman, Dane M;Braun, Asolina;Masson, Frederick;Kallies, Axel;Belz, Gabrielle T;Carbone, Francis R
Affiliation: Department of Microbiology and Immunology, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Parkville, Victoria 3010, Australia
Australian Research Council Centre of Excellence for Advanced Molecular Imaging, University of Melbourne, Parkville, Victoria 3010, Australia
Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia
School of Cancer Medicine, La Trobe University, Melbourne, Victoria 3086, Australia
Issue Date: 15-Dec-2015
Citation: Immunity 2015; 43(6): 1101-11
Abstract: Tissue-resident memory T (Trm) cells contribute to local immune protection in non-lymphoid tissues such as skin and mucosa, but little is known about their transcriptional regulation. Here we showed that CD8(+)CD103(+) Trm cells, independent of circulating memory T cells, were sufficient for protection against infection and described molecular elements that were crucial for their development in skin and lung. We demonstrated that the T-box transcription factors (TFs) Eomes and T-bet combined to control CD8(+)CD103(+) Trm cell formation, such that their coordinate downregulation was crucial for TGF-β cytokine signaling. TGF-β signaling, in turn, resulted in reciprocal T-box TF downregulation. However, whereas extinguishment of Eomes was necessary for CD8(+)CD103(+) Trm cell development, residual T-bet expression maintained cell surface interleukin-15 (IL-15) receptor β-chain (CD122) expression and thus IL-15 responsiveness. These findings indicate that the T-box TFs control the two cytokines, TGF-β and IL-15, which are pivotal for CD8(+)CD103(+) Trm cell development and survival.
URI: http://ahro.austin.org.au/austinjspui/handle/1/18625
DOI: 10.1016/j.immuni.2015.11.008
PubMed URL: 26682984
Type: Journal Article
Research Support, Non-U.S. Gov't
Subjects: T-box transcription factors
TGF-β
Tissue-resident memory T cells
peripheral immunity
Appears in Collections:Journal articles

Files in This Item:
There are no files associated with this item.


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.