Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/18624
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dc.contributor.authorThijs, Vincent N-
dc.contributor.authorBrachmann, Johannes-
dc.contributor.authorMorillo, Carlos A-
dc.contributor.authorPassman, Rod S-
dc.contributor.authorSanna, Tommaso-
dc.contributor.authorBernstein, Richard A-
dc.contributor.authorDiener, Hans-Christoph-
dc.contributor.authorDi Lazzaro, Vincenzo-
dc.contributor.authorRymer, Marilyn M-
dc.contributor.authorHogge, Laurence-
dc.contributor.authorRogers, Tyson B-
dc.contributor.authorZiegler, Paul D-
dc.contributor.authorAssar, Manish D-
dc.date2015-12-18-
dc.date.accessioned2018-08-30T06:34:03Z-
dc.date.available2018-08-30T06:34:03Z-
dc.date.issued2016-01-19-
dc.identifier.citationNeurology 2016; 86(3): 261-9-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/18624-
dc.description.abstractWe assessed predictors of atrial fibrillation (AF) in cryptogenic stroke (CS) or transient ischemic attack (TIA) patients who received an insertable cardiac monitor (ICM). We studied patients with CS/TIA who were randomized to ICM within the CRYSTAL AF study. We assessed whether age, sex, race, body mass index, type and severity of index ischemic event, CHADS2 score, PR interval, and presence of diabetes, hypertension, congestive heart failure, or patent foramen ovale and premature atrial contractions predicted AF development within the initial 12 and 36 months of follow-up using Cox proportional hazards models. Among 221 patients randomized to ICM (age 61.6 ± 11.4 years, 64% male), AF episodes were detected in 29 patients within 12 months and 42 patients at 36 months. Significant univariate predictors of AF at 12 months included age (hazard ratio [HR] per decade 2.0 [95% confidence interval 1.4-2.8], p = 0.002), CHADS2 score (HR 1.9 per one point [1.3-2.8], p = 0.008), PR interval (HR 1.3 per 10 milliseconds [1.2-1.4], p < 0.0001), premature atrial contractions (HR 3.9 for >123 vs 0 [1.3-12.0], p = 0.009 across quartiles), and diabetes (HR 2.3 [1.0-5.2], p < 0.05). In multivariate analysis, age (HR per decade 1.9 [1.3-2.8], p = 0.0009) and PR interval (HR 1.3 [1.2-1.4], p < 0.0001) remained significant and together yielded an area under the receiver operating characteristic curve of 0.78 (0.70-0.85). The same predictors were found at 36 months. Increasing age and a prolonged PR interval at enrollment were independently associated with an increased AF incidence in CS patients. However, they offered only moderate predictive ability in determining which CS patients had AF detected by the ICM.-
dc.language.isoeng-
dc.titlePredictors for atrial fibrillation detection after cryptogenic stroke: Results from CRYSTAL AF.-
dc.typeJournal Article-
dc.identifier.journaltitleNeurology-
dc.identifier.affiliationBaylor University Medical Center, Dallas, TXen
dc.identifier.affiliationThe Florey Institute of Neuroscience and Mental Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationDepartment of Neurology, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationMedtronic, Maastricht, Netherlandsen
dc.identifier.affiliationMedtronic, Mounds View, Minneapolis, MNen
dc.identifier.affiliationHospital Klinikum Coburg, Teaching Hospital of the University of Würzburg, Coburg, Germanyen
dc.identifier.affiliationPopulation Health Research Institute, McMaster University, Hamilton, Canadaen
dc.identifier.affiliationNorthwestern University Feinberg School of Medicine, Chicago, IL, USAen
dc.identifier.affiliationInstitute of Cardiology, Catholic University of the Sacred Heart, Rome, Italyen
dc.identifier.affiliationDavee Department of Neurology, Northwestern University, Chicago, IL, USAen
dc.identifier.affiliationDepartment of Neurology, University Hospital Essen University Duisburg-Essen, Germanyen
dc.identifier.affiliationInstitute of Neurology, University Campus Bio-Medico of Rome, Rome, Italyen
dc.identifier.affiliationUniversity of Kansas Medical Center, Kansas City, USAen
dc.identifier.doi10.1212/WNL.0000000000002282-
dc.identifier.orcid0000-0002-6614-8417-
dc.identifier.pubmedid26683642-
dc.type.austinJournal Article-
dc.type.austinResearch Support, Non-U.S. Gov't-
local.name.researcherThijs, Vincent N
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptNeurology-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
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