Please use this identifier to cite or link to this item:
|Title:||Dose-adjusted arsenic trioxide for acute promyelocytic leukaemia in chronic renal failure.|
|Authors:||Firkin, Frank;Roncolato, Fernando;Ho, Wai Khoon|
|Affiliation:||Department of Medicine, St Vincent's Hospital, Melbourne University, Fitzroy, Vic., Australia|
Department of Haematology, St George Hospital, Kogarah, NSW, Australia
Department of Haematology, Austin Health, Heidelberg, Victoria, Australia
|Citation:||European journal of haematology 2015; 95(4): 331-5|
|Abstract:||To determine the potential for arsenic trioxide (ATO) to be safely and effectively incorporated into induction therapy of newly diagnosed acute promyelocytic leukaemia (APL) in patients with severe chronic renal failure (CRF) by reduction of the ATO dosage to compensate for reduced renal elimination of arsenic in CRF. Two of the four CRF patients with APL in the study were dialysis-dependent, and two had eGFRs of 18 and 19 mL/min/1.73 m(2) . ATO dosage schedules were adjusted to obtain comparable whole-blood arsenic levels to those in APL patients with normal renal function who achieved molecular remission (MR) while receiving 10 mg ATO daily for 28 d. Average ATO administered per day in CRF patients ranged from 36 to 50% of the ATO administered to APL patients with normal renal function. No clinically significant cardiac, hepatic or other toxicities were detected. RT-PCR-negative MR was achieved after one treatment course in two patients and after two courses in the others. Relapse-free survival is 155, 60, 43 and 5 months. The observations in this pilot study have demonstrated whole-blood arsenic levels can provide a guide to adjustments of ATO dosage schedules that permit safe and effective therapeutic outcomes in APL patients with severely compromised renal function.|
|Subjects:||acute promyelocytic leukaemia|
arsenic blood level monitoring
chronic renal failure
|Appears in Collections:||Journal articles|
Files in This Item:
There are no files associated with this item.
Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.