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Title: A critical review of chronic traumatic encephalopathy.
Authors: Iverson, Grant L;Gardner, Andrew J;McCrory, Paul R;Zafonte, Ross;Castellani, Rudy J
Affiliation: Centre for Translational Neuroscience and Mental Health, School of Medicine and Public Health, University of Newcastle, Callaghan, NSW, Australia
Hunter New England Local Health District Sports Concussion Program, University of Newcastle, Callaghan, NSW, Australia
Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, MA, USA
Spaulding Rehabilitation Hospital, MassGeneral Hospital for Children Sports Concussion Program, Boston, MA, USA
The Florey Institute of Neuroscience and Mental Health, Heidelberg, Victoria, Australia
Red Sox Foundation and Massachusetts General Hospital Home Base Program, Boston, MA, USA
Division of Neuropathology, University of Maryland School of Medicine, USA
Issue Date: Sep-2015
EDate: 2015-07-14
Citation: Neuroscience and biobehavioral reviews 2015; 56: 276-293
Abstract: Chronic traumatic encephalopathy (CTE) has been described in the literature as a neurodegenerative disease with: (i) localized neuronal and glial accumulations of phosphorylated tau (p-tau) involving perivascular areas of the cerebral cortex, sulcal depths, and with a preference for neurons within superficial cortical laminae; (ii) multifocal axonal varicosities and axonal loss involving deep cortex and subcortical white matter; (iii) relative absence of beta-amyloid deposits; (iv) TDP-43 immunoreactive inclusions and neurites; and (v) broad and diverse clinical features. Some of the pathological findings reported in the literature may be encountered with age and other neurodegenerative diseases. However, the focality of the p-tau cortical findings in particular, and the regional distribution, are believed to be unique to CTE. The described clinical features in recent cases are very similar to how depression manifests in middle-aged men and with frontotemporal dementia as the disease progresses. It has not been established that the described tau pathology, especially in small amounts, can cause complex changes in behavior such as depression, substance abuse, suicidality, personality changes, or cognitive impairment. Future studies will help determine the extent to which the neuropathology is causally related to the diverse clinical features.
DOI: 10.1016/j.neubiorev.2015.05.008
PubMed URL: 26183075
Type: Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Subjects: Athletes
Brain injury
Dementia pugilistica
Appears in Collections:Journal articles

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