Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/18590
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dc.contributor.authorJohnstone, Cameron N-
dc.contributor.authorChand, Ashwini-
dc.contributor.authorPutoczki, Tracy L-
dc.contributor.authorErnst, Matthias-
dc.date2015-07-14-
dc.date.accessioned2018-08-30T06:23:39Z-
dc.date.available2018-08-30T06:23:39Z-
dc.date.issued2015-10-
dc.identifier.citationCytokine & growth factor reviews 2015; 26(5): 489-98-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/18590-
dc.description.abstractInterleukin (IL)-11 is a member of the IL-6 family of cytokines that is defined by the shared use of the GP130 signal transducing receptor subunit. In addition of its long recognized activities as a hemopoietic growth factor, IL-11 has an emerging role in epithelial cancer biology. Through the activation of the GP130-Janus kinase signaling cascade and associated transcription factor STAT3, IL-11 can confer many of the tumor intrinsic 'hallmark' capabilities to neoplastic cells, if they express the ligand-specific IL-11Rα receptor subunit. Accordingly, IL-11 signaling has recently been identified as a rate-limiting step for the growth tumors arising from the mucosa of the gastrointestinal tract. However, there is less appreciation for a potential role of IL-11 to support breast cancer progression, apart from its well documented capacity to facilitate bone metastasis. Here we review evidence that IL-11 expression in breast cancer correlates with poor disease outcome and discuss some of the molecular mechanisms that are likely to underpin these observations. These include the capacity of IL-11 to stimulate survival and proliferation of cancer cells alongside angiogenesis of the primary tumor and of metastatic progenies at distant organs. We review current strategies to interfere with IL-11 signaling and advocate that inhibition of IL-11 signaling may represent an emerging therapeutic opportunity for numerous cancers.-
dc.language.isoeng-
dc.subjectCancer-
dc.subjectIL-11-
dc.subjectIL-6-
dc.subjectInterleukin-
dc.subjectSTAT3-
dc.titleEmerging roles for IL-11 signaling in cancer development and progression: Focus on breast cancer.-
dc.typeJournal Article-
dc.identifier.journaltitleCytokine & growth factor reviews-
dc.identifier.affiliationCancer & Inflammation Laboratory, Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia-
dc.identifier.affiliationSchool of Cancer Medicine, LaTrobe University, Heidelberg, VIC 3084, Australia-
dc.identifier.affiliationDepartment of Medical Biology, Melbourne University, Parkville, Victoria, Australia-
dc.identifier.affiliationOlivia Newton-John Cancer Wellness and Research Centre, Austin Health, Heidelberg, Victoria, Australia-
dc.identifier.affiliationInflammation Division, Walter & Eliza Hall Institute of Medical Research, Parkville, Victoria, Australiaen
dc.identifier.affiliationCancer Metastasis Laboratory, Cancer Research Division, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australiaen
dc.identifier.doi10.1016/j.cytogfr.2015.07.015-
dc.identifier.orcid0000-0002-6399-1177-
dc.identifier.pubmedid26209885-
dc.type.austinJournal Article-
dc.type.austinResearch Support, Non-U.S. Gov't-
dc.type.austinReview-
local.name.researcherErnst, Matthias
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptOlivia Newton-John Cancer Research Institute-
crisitem.author.deptOlivia Newton-John Cancer Research Institute-
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