Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/18582
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dc.contributor.authorGorringe, Kylie L-
dc.contributor.authorHunter, Sally M-
dc.contributor.authorPang, Jia-Min-
dc.contributor.authorOpeskin, Ken-
dc.contributor.authorHill, Prue-
dc.contributor.authorRowley, Simone M-
dc.contributor.authorChoong, David Y H-
dc.contributor.authorThompson, Ella R-
dc.contributor.authorDobrovic, Alexander-
dc.contributor.authorFox, Stephen B-
dc.contributor.authorMann, G Bruce-
dc.contributor.authorCampbell, Ian G-
dc.date2015-06-19-
dc.date.accessioned2018-08-30T06:23:39Z-
dc.date.available2018-08-30T06:23:39Z-
dc.date.issued2015-09-
dc.identifier.citationModern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2015; 28(9): 1174-84-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/18582-
dc.description.abstractDuctal carcinoma in situ (DCIS) is a non-obligate precursor of invasive breast cancer and a frequent mammographic finding requiring treatment. Up to 25% of DCIS can recur and half of recurrences are invasive, but there are no reliable biomarkers for recurrence. We hypothesised that copy number aberrations could predict likelihood of recurrence. We analysed a cohort of pure DCIS cases treated only with wide local excision for genome-wide copy number and loss of heterozygosity using Affymetrix OncoScan MIP arrays. Cases included those without recurrence within 7 years (n = 25) and with recurrence between 1 and 5 years after diagnosis (n = 15). Pure DCIS were broadly similar in copy number changes compared with invasive breast cancer, with the consistent exception of a greater frequency of ERBB2 amplification in DCIS. There were no significant differences in age or ER status between the cases with a recurrence vs those without. Overall, the DCIS cases with recurrence had more copy number events than the DCIS without recurrence. The increased copy number appeared non-random with several genomic regions showing an increase in frequency in recurrent cases, including 20 q gain, ERBB2 amplification and 15q loss. Copy number changes may provide prognostic information for DCIS recurrence, but validation in additional cohorts is required.-
dc.language.isoeng-
dc.titleCopy number analysis of ductal carcinoma in situ with and without recurrence.-
dc.typeJournal Article-
dc.identifier.journaltitleModern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc-
dc.identifier.affiliationThe Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australiaen
dc.identifier.affiliationCancer Genetics Laboratory, Peter MacCullum Cancer Centre, East Melbourne, Victoria, Australia-
dc.identifier.affiliationDepartment of Pathology, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australiaen
dc.identifier.affiliationDepartment of Surgery, University of Melbourne, Melbourne, Victoria, Australiaen
dc.identifier.affiliationThe Royal Melbourne and Royal Women's Hospitals, Parkville, Victoria, Australiaen
dc.identifier.affiliationDepartment of Anatomical Pathology, St Vincent's Hospital, Fitzroy, Victoria, Australiaen
dc.identifier.affiliationDepartment of Pathology, University of Melbourne, Melbourne, Victoria, Australiaen
dc.identifier.affiliationTranslational Genomics and Epigenomics Laboratory, Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationSchool of Cancer Medicine, La Trobe University, Melbourne, Victoria, Australia en
dc.identifier.doi10.1038/modpathol.2015.75-
dc.identifier.orcid0000-0003-3414-112Xen
dc.identifier.orcid0000-0001-5681-2022en
dc.identifier.pubmedid26321097-
dc.type.austinJournal Article-
dc.type.austinResearch Support, Non-U.S. Gov't-
local.name.researcherDobrovic, Alexander
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptOlivia Newton-John Cancer Research Institute-
crisitem.author.deptSurgery (University of Melbourne)-
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