Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/18403
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dc.contributor.authorLee, Hyon-
dc.contributor.authorSeo, Seongho-
dc.contributor.authorLee, Sang-Yoon-
dc.contributor.authorJeong, Hye Jin-
dc.contributor.authorWoo, Sung-Ho-
dc.contributor.authorLee, Kyoung-Min-
dc.contributor.authorLee, Yeong-Bae-
dc.contributor.authorPark, Kee Hyung-
dc.contributor.authorHeo, Jae-Hyeok-
dc.contributor.authorYoon, Cindy W-
dc.contributor.authorKang, Jae Myeong-
dc.contributor.authorCho, Jaelim-
dc.contributor.authorOkamura, Nobuyuki-
dc.contributor.authorFurumoto, Shozo-
dc.contributor.authorYanai, Kazuhiko-
dc.contributor.authorNa, Duk L-
dc.contributor.authorIdo, Tatsuo-
dc.contributor.authorVillemagne, Victor L-
dc.contributor.authorNoh, Young-
dc.date.accessioned2018-08-30T05:58:48Z-
dc.date.available2018-08-30T05:58:48Z-
dc.date.issued2018-01-
dc.identifier.citationAlzheimer disease and associated disorders 2018; 32(1): 62-69en
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/18403-
dc.description.abstractSemantic variant primary progressive aphasia (svPPA) has been associated with a variety of proteinopathies, mainly transactive response DNA-binding protein, but also with tau and β-amyloid. Recently selective tau tracers for positron emission tomography (PET) have been developed to determine the presence of cerebral tau deposits in vivo. Here, we investigated the topographical distribution of THK5351 in svPPA patients. Five svPPA patients, 14 Alzheimer's disease patients, and 15 age-matched normal controls underwent [F]-THK5351 PET scans, magnetic resonance imaging, and detailed neuropsychological tests. [F]-fluorodeoxyglucose PET was obtained in 3 svPPA patients, whereas the remaining 2 underwent amyloid PET using [F]-flutemetamol. Tau distribution among the 3 groups was compared using regions of interest-based and voxel-based statistical analyses. In svPPA patients, [F]-THK5351 retention was elevated in the anteroinferior and lateral temporal cortices compared with the normal controls group (left>right), and in the left inferior and temporal polar region compared with Alzheimer's disease patients. [F]-THK5351 retention inversely correlated with glucose metabolism, whereas regional THK retention correlated with clinical severity. [F]-flutemetamol scans were negative for β-amyloid. These findings show that [F]-THK5351 retention may be detected in cortical regions correlating with svPPA pathology.en
dc.language.isoeng-
dc.title[18F]-THK5351 PET Imaging in Patients With Semantic Variant Primary Progressive Aphasia.en
dc.typeJournal Articleen
dc.identifier.journaltitleAlzheimer disease and associated disordersen
dc.identifier.affiliationDepartments of Neurologyen
dc.identifier.affiliationDepartment of Neuroscience, College of Medicineen
dc.identifier.affiliationNeuroscience Center, Samsung Medical Center, Seoul, Republic of Koreaen
dc.identifier.affiliationDepartments of Neurologyen
dc.identifier.affiliationDepartment of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicineen
dc.identifier.affiliationDepartment of Health Science and Technology, GAIHST, Gachon Universityen
dc.identifier.affiliationNeuroscience Research Instituteen
dc.identifier.affiliationDepartment of Neurology, Seoul National University Hospitalen
dc.identifier.affiliationDepartment of Neurology, Seoul Medical Centeren
dc.identifier.affiliationDepartment of Neurology, Inha University School of Medicine, Incheonen
dc.identifier.affiliationPsychiatryen
dc.identifier.affiliationOccupational and Environmental Medicine, Gachon University Gil Medical Centeren
dc.identifier.affiliationCyclotron and Radioisotope Center, Tohoku University, Sendai, Japanen
dc.identifier.affiliationDepartment of Pharmacology, Tohoku Medical and Pharmaceutical Universityen
dc.identifier.affiliationDepartment of Molecular Imaging and Therapy, Centre for PET, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationThe Florey Institute of Neuroscience and Mental Health, the University of Melbourne, Melbourne, Victoria, Australiaen
dc.identifier.doi10.1097/WAD.0000000000000216en
dc.type.contentTexten
dc.identifier.pubmedid29028649-
dc.type.austinJournal Article-
local.name.researcherVillemagne, Victor L
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptMolecular Imaging and Therapy-
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