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|Title:||Outcomes following front-line chemotherapy in peripheral T-cell lymphoma: 10-year experience at The Royal Marsden and The Christie Hospital.|
|Authors:||Gleeson, Mary;Peckitt, Clare;Cunningham, David;Gibb, Adam;Hawkes, Eliza A;Back, Morgan;Yasar, Binnaz;Foley, Kate;Lee, Rebecca;Dash, Joanna;Johnson, Hannah;O'Hara, Catherine;Wotherspoon, Andrew;Attygalle, Ayoma;Menasce, Lia;Shenjere, Patrick;Potter, Mike;Ethell, Mark E;Dearden, Claire;Radford, John;Chau, Ian;Linton, Kim|
|Affiliation:||The Royal Marsden Hospital, London and Surrey , UK|
Department of Clinical Haematology, Austin Health, Heidelberg, Victoria, Australia
Department of Oncology, Austin Health, Heidelberg, Victoria, Australia
Eastern Health, Melbourne, Australia
The University of Manchester and The Christie NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK
|Citation:||Leukemia & lymphoma 2018; 59(7): 1586-1595|
|Abstract:||We evaluated the outcomes for patients with peripheral T-cell lymphoma (PTCL) undergoing front-line chemotherapy at our institutions between 2002 and 2012. One hundred and fifty-six patients were eligible, comprising PTCL not otherwise specified (NOS) (n = 50, 32.0%), angioimmunoblastic T-cell lymphoma (AITL) (n = 44, 28.2%), anaplastic large-cell lymphoma (ALCL) ALK negative (n = 23, 14.7%), ALCL ALK positive (n = 16, 10.3%), and other (n = 23, 14.7%). Most patients received CHOP (66.0%) and 13.0% received an autologous hematopoietic progenitor cell transplant (HPCT). With a median follow-up of 63.4 months, 5-year overall survival (OS) and progression-free survival (PFS) was 38.8% and 19.8% respectively. Independent risk factors for inferior OS were age >60 years, International Prognostic Index (IPI) ≥ 2 and lack of complete response to induction. When responding patients were compared by receipt of an autologous HPCT versus not, HPCT was associated with improved PFS (p = .001) and OS (p = .046) and remained significant for PFS in multivariate analysis suggesting a possible therapeutic benefit.|
|Subjects:||Peripheral T-cell lymphoma|
hematopoietic progenitor cell transplant
|Appears in Collections:||Journal articles|
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