Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/18269
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dc.contributor.authorNavitsky, Michael-
dc.contributor.authorJoshi, Abhinay D-
dc.contributor.authorKennedy, Ian-
dc.contributor.authorKlunk, William E-
dc.contributor.authorRowe, Christopher C-
dc.contributor.authorWong, Dean F-
dc.contributor.authorPontecorvo, Michael J-
dc.contributor.authorMintun, Mark A-
dc.contributor.authorDevous, Michael D-
dc.date2018-07-10-
dc.date.accessioned2018-08-27T05:26:24Z-
dc.date.available2018-08-27T05:26:24Z-
dc.date.issued2018-
dc.identifier.citationAlzheimer's & dementia 2018; 14(12): 1565-1571-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/18269-
dc.description.abstractKlunk et al. recently proposed a means of standardizing quantitation of amyloid burden from positron emission tomography scans to a common Centiloid scale, and we have applied that method to florbetapir. Florbetapir and Pittsburgh compound B scans were acquired for 46 mixed clinical presentation subjects within 18 ± 20 days. Florbetapir and Pittsburgh compound B cortical standardized uptake value ratio (SUVr) values were well correlated for both standard Centiloid (R2 = 0.894) and Avid (R2 = 0.901) volume of interests (VOIs). The methods of Klunk et al. were applied to establish a conversion first from florbetapir SUVr values obtained using standard Centiloid VOIs to Centiloids and then from Avid VOIs (Joshi et al.) to Centiloids. The equation for conversion of florbetapir SUVr from Avid VOIs to the Centiloid scale was as follows: Florbetapir Centiloids = 183 × SUVrAvid - 177. The threshold that discriminated neuropathologically verified none or sparse versus moderate to frequent plaques in autopsy-confirmed data is 24.1 Centiloids. These findings may allow improved tracer-independent amyloid quantitation.-
dc.language.isoeng-
dc.subjectAmyloid imaging-
dc.subjectCentiloids-
dc.subjectFlorbetapir-
dc.subjectPittsburgh compound B-
dc.titleStandardization of amyloid quantitation with florbetapir standardized uptake value ratios to the Centiloid scale.-
dc.typeJournal Article-
dc.identifier.journaltitleAlzheimer's & dementia : the journal of the Alzheimer's Association-
dc.identifier.affiliationDepartments of Neurology and Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA-
dc.identifier.affiliationRadiology, Psychiatry, Neuroscience, Neurology, Environmental Health Sciences, and Carey Business School, Johns Hopkins University, Section of High Resolution Brain PET Imaging, Division of Nuclear Medicine, Baltimore, MD, USA-
dc.identifier.affiliationAvid Radiopharmaceuticals, Philadelphia, PA, USA-
dc.identifier.affiliationDepartment of Nuclear Medicine & Centre for PET, Austin Health, Heidelberg, Victoria, Australia-
dc.identifier.affiliationDepartment of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia-
dc.identifier.doi10.1016/j.jalz.2018.06.1353-
dc.identifier.orcid0000-0003-3910-2453-
dc.identifier.pubmedid30006100-
dc.type.austinJournal Article-
local.name.researcherRowe, Christopher C
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptMolecular Imaging and Therapy-
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