Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/18165
Full metadata record
DC FieldValueLanguage
dc.contributor.authorWhite, V M-
dc.contributor.authorSkaczkowski, Gemma-
dc.contributor.authorPinkerton, R-
dc.contributor.authorCoory, M-
dc.contributor.authorOsborn, M-
dc.contributor.authorBibby, H-
dc.contributor.authorNicholls, W-
dc.contributor.authorOrme, L M-
dc.contributor.authorConyers, R-
dc.contributor.authorPhillips, M B-
dc.contributor.authorHarrup, R-
dc.contributor.authorWalker, R-
dc.contributor.authorThompson, K-
dc.contributor.authorAnazodo, A-
dc.date2018-07-24-
dc.date.accessioned2018-08-08T01:03:19Z-
dc.date.available2018-08-08T01:03:19Z-
dc.date.issued2018-11-
dc.identifier.citationPediatric blood & cancer 2018; 65(11): e27349-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/18165-
dc.description.abstractWhile several studies have examined the treatment of adolescents and young adults (AYAs) with acute lymphoblastic leukemia (ALL), studies of acute myeloid leukemia (AML) are rare. Using national data for Australia, we describe (i) the number and type of treatment centers caring for AYAs, (ii) induction/first-line treatments, and (iii) survival outcomes. National population-based study assessing treatment of 15- to 24-year-olds diagnosed with ALL or AML between 2007 and 2012. Treatment details were abstracted from hospital medical records. Treatment centers were classified as pediatric or adult (adult AYA-focused or other adult; and by AYA volume [high/low]). Cox proportional hazard regression analyses examined associations between treatment and overall, event-free, and relapse-free survival outcomes. Forty-seven hospitals delivered induction therapy to 351 patients (181 ALL and 170 AML), with 74 (21%) treated at pediatric centers; 70% of hospitals treated less than two AYA leukemia patients per year. Regardless of treatment center, 82% of ALL patients were on pediatric protocols. For AML, pediatric protocols were not used in adult centers, with adult centers using a non-COG 7+3-type induction protocol (51%, where COG is Cooperative Oncology Group) or an ICE-type protocol (39%, where ICE is idarubicin, cytarabine, etoposide). Exploratory analyses suggested that for both ALL and AML, AYAs selected for adult protocols have worse overall, event-free, and relapse-free survival outcomes. Pediatric protocols were commonly used for ALL patients regardless of where they are treated, indicating rapid assimilation of recent evidence by Australian hematologists. For AML, pediatric protocols were only used at pediatric centers. Further investigation is warranted to determine the optimal treatment approach for AYA AML patients.-
dc.language.isoeng-
dc.subjectALL-
dc.subjectAML-
dc.subjectadolescents and young adults-
dc.subjectpopulation-based study-
dc.subjectsurvival-
dc.subjecttreatment-
dc.titleClinical management of Australian adolescents and young adults with acute lymphoblastic and myeloid leukemias: A national population-based study.-
dc.typeJournal Article-
dc.identifier.journaltitlePediatric blood & cancer-
dc.identifier.affiliationCentre for Behavioural Research in Cancer, Cancer Council Victoria, Melbourne, Victoria, Australia-
dc.identifier.affiliationSchool of Psychology, Deakin University, Burwood, Victoria, Australia-
dc.identifier.affiliationSchool of Psychology and Public Health, La Trobe University, Bundoora, Victoria, Australia-
dc.identifier.affiliationOlivia Newton-John Cancer Wellness and Research Centre, Austin Health, Heidelberg, Victoria, Australia-
dc.identifier.affiliationChildren's Health Queensland Hospital and Health Service, Brisbane, Queensland, Australia-
dc.identifier.affiliationChildren's Cancer Centre, The Royal Children's Hospital, Melbourne, Victoria, Australia-
dc.identifier.affiliationRoyal Adelaide Hospital, South Australia, Adelaide, Australia-
dc.identifier.affiliationPeter MacCallum Cancer Centre, Melbourne, Victoria, Australia-
dc.identifier.affiliationPrincess Margaret Hospital for Children, Perth, Western Australia, Australia-
dc.identifier.affiliationRoyal Hobart Hospital, Hobart, Tasmania, Australia-
dc.identifier.affiliationKids Cancer Centre, Sydney Children's Hospital, Randwick, New South Wales, Australia-
dc.identifier.affiliationNelune Comprehensive Cancer Centre, Prince of Wales Hospital, Randwick, New South Wales, Australia-
dc.identifier.affiliationSchool of Women's and Children's Health, University of New South Wales, Randwick, New South Wales, Australia-
dc.identifier.doi10.1002/pbc.27349-
dc.identifier.orcid0000-0001-6619-8484-
dc.identifier.orcid0000-0003-0715-3563-
dc.identifier.orcid0000-0002-2344-1365-
dc.identifier.pubmedid30039912-
dc.type.austinJournal Article-
local.name.researcherSkaczkowski, Gemma
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.languageiso639-1en-
crisitem.author.deptOlivia Newton-John Cancer Wellness and Research Centre-
crisitem.author.deptPsycho-Oncology Research Unit-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

24
checked on Mar 27, 2024

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.