Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/18071
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dc.contributor.authorLee, Darren-
dc.contributor.authorWhitlam, John B-
dc.contributor.authorCook, Natasha-
dc.contributor.authorWalker, Amanda M-
dc.contributor.authorRoberts, Matthew A-
dc.contributor.authorIerino, Francesco L-
dc.contributor.authorKausman, Joshua Y-
dc.date2018-05-30-
dc.date.accessioned2018-07-10T06:36:54Z-
dc.date.available2018-07-10T06:36:54Z-
dc.date.issued2018-
dc.identifier.citationTransplant international : official journal of the European Society for Organ Transplantation 2018; 31(10): 1144-1152-
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/18071-
dc.description.abstractLiving kidney donors (LKD) for paediatric kidney transplant recipients (KTR) have a heightened motivation to donate for emotional reasons and the clear health benefits to the KTR. We hypothesized that the cohort of LKD for paediatric KTR (LKD-P) includes motivated young parents with a higher lifetime end-stage kidney disease (ESKD) risk compared to adult KTR (LKD-A). Data from the Australia and New Zealand Dialysis and Transplant LKD Registry (2004-2015) was analysed to compare baseline characteristics and predonation ESKD risk in LKD-P (n = 315) versus LKD-A (n = 3448). LKD-P were younger (median age 42 vs. 50 years; P < 0.001) and had a marginally higher lifetime ESKD risk (median 0.44% vs. 0.40%; P < 0.01), with a similar proportion of LKD exceeding 1% risk threshold (5.4% vs. 5.6%; P = NS). Compared to grandparents as LKD-P, parents (median age 41 vs. 59 years; P < 0.001) had a higher lifetime ESKD (0.44% vs. 0.25%; P < 0.001). Although unique benefits to paediatric KTR justify the minor increase in lifetime ESKD risk in young parents, carefully selected grandparents are an alternative LKD-P option, allowing parents to donate for subsequent transplants.-
dc.language.isoeng-
dc.subjectliving donors-
dc.subjectpaediatric kidney transplantation-
dc.titleLifetime risk of end-stage kidney disease in living donors for paediatric kidney transplant recipients in Australia and New Zealand - a retrospective study.-
dc.typeJournal Article-
dc.identifier.journaltitleTransplant international : official journal of the European Society for Organ Transplantation-
dc.identifier.affiliationDepartment of Renal Medicine, Eastern Health, Box Hill, Vic., Australia-
dc.identifier.affiliationEastern Health Clinical School, Monash University, Clayton, Vic., Australia-
dc.identifier.affiliationDepartment of Nephrology, Austin Health, Heidelberg, Victoria, Australia Australia-
dc.identifier.affiliationUniversity of Melbourne, Parkville, Vic., Australia-
dc.identifier.affiliationDepartment of Nephrology, Royal Children's Hospital, Parkville, Vic., Australia-
dc.identifier.affiliationMurdoch Children's Research Institute, Parkville, Vic., Australia-
dc.identifier.affiliationDepartment of Nephrology, St Vincent's Hospital Melbourne, Fitzroy, Vic., Australia-
dc.identifier.doi10.1111/tri.13284-
dc.identifier.orcid0000-0002-3771-9102-
dc.identifier.pubmedid29846984-
Appears in Collections:Journal articles

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