Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/18071
Title: Lifetime risk of end-stage kidney disease in living donors for paediatric kidney transplant recipients in Australia and New Zealand - a retrospective study.
Authors: Lee, Darren;Whitlam, John B;Cook, Natasha;Walker, Amanda M;Roberts, Matthew A;Ierino, Francesco L;Kausman, Joshua Y
Affiliation: Department of Renal Medicine, Eastern Health, Box Hill, Vic., Australia
Eastern Health Clinical School, Monash University, Clayton, Vic., Australia
Department of Nephrology, Austin Health, Heidelberg, Victoria, Australia Australia
University of Melbourne, Parkville, Vic., Australia
Department of Nephrology, Royal Children's Hospital, Parkville, Vic., Australia
Murdoch Children's Research Institute, Parkville, Vic., Australia
Department of Nephrology, St Vincent's Hospital Melbourne, Fitzroy, Vic., Australia
Issue Date: 30-May-2018
EDate: 2018-05-30
Citation: Transplant international : official journal of the European Society for Organ Transplantation 2018; online first: 30 May
Abstract: Living kidney donors (LKD) for paediatric kidney transplant recipients (KTR) have a heightened motivation to donate for emotional reasons and the clear health benefits to the KTR. We hypothesized that the cohort of LKD for paediatric KTR (LKD-P) includes motivated young parents with a higher lifetime end-stage kidney disease (ESKD) risk compared to adult KTR (LKD-A). Data from the Australia and New Zealand Dialysis and Transplant LKD Registry (2004-2015) was analysed to compare baseline characteristics and predonation ESKD risk in LKD-P (n = 315) versus LKD-A (n = 3448). LKD-P were younger (median age 42 vs. 50 years; P < 0.001) and had a marginally higher lifetime ESKD risk (median 0.44% vs. 0.40%; P < 0.01), with a similar proportion of LKD exceeding 1% risk threshold (5.4% vs. 5.6%; P = NS). Compared to grandparents as LKD-P, parents (median age 41 vs. 59 years; P < 0.001) had a higher lifetime ESKD (0.44% vs. 0.25%; P < 0.001). Although unique benefits to paediatric KTR justify the minor increase in lifetime ESKD risk in young parents, carefully selected grandparents are an alternative LKD-P option, allowing parents to donate for subsequent transplants.
URI: http://ahro.austin.org.au/austinjspui/handle/1/18071
DOI: 10.1111/tri.13284
ORCID: 0000-0002-3771-9102
PubMed URL: 29846984
Type: Journal Article
Subjects: living donors
paediatric kidney transplantation
Appears in Collections:Journal articles

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