Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/18044
Title: Sleep problems in Dravet syndrome: a modifiable comorbidity.
Authors: Licheni, Shane H;Mcmahon, Jacinta M;Schneider, Amy L;Davey, Margot J;Scheffer, Ingrid E
Affiliation: Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia
Melbourne Children's Sleep Centre, Monash Children's Hospital, Melbourne, Australia
The Florey Institute of Neuroscience and Mental Health, Melbourne, Australia
Department of Neurology and Department of Paediatrics, University of Melbourne, Royal Children's Hospital, Melbourne, Australia
Issue Date: Feb-2018
EDate: 2017-11-07
Citation: Developmental medicine and child neurology 2018; 60(2): 192-198
Abstract: Many children with severe developmental and epileptic encephalopathies experience significant sleep disturbance, causing major disruption to the family's quality of life. We aimed to determine the frequency and nature of sleep problems in individuals with Dravet syndrome. The Sleep Disturbance Scale for Children and a seizure questionnaire were distributed to the parents/guardians of 96 patients with Dravet syndrome. Sixteen patients had two nights of home oximetry. Fifty-seven out of 96 questionnaires were completed. Forty-three out of 57 (75%) individuals had sleep problems. Twenty-five out of 57 (44%) individuals had an abnormal total sleep score, with difficulty initiating and maintaining sleep (22 out of 57, 39%), sleep-wake transition disorders (20 out of 57, 35%), and sleep breathing disorders (19 out of 57, 33%). Twenty-two out of 57 (39%) individuals took medication to assist sleep, predominantly melatonin (n=14). Thirty out of 57 (53%) recently had nocturnal seizures. Overnight oximetry showed 14 out of 16 (88%) had a higher oxygen desaturation index (>3%), and six out of 16 (38%) had higher mean pulse rates than normative values. Home oximetry was normal or inconclusive in all patients. Seventy-five per cent of individuals with Dravet syndrome had sleep problems, highlighting the importance of routinely assessing sleep and initiating appropriate behavioural and pharmacological interventions to improve the patient and family's quality of life. A high oxygen desaturation index and mean pulse rates on pulse oximetry may reflect unrecognized nocturnal seizures. More than 70% of patients with Dravet syndrome have sleep problems. Difficulty initiating and maintaining sleep was most common, particularly in those older than 20 years. Second most common were sleep-wake transition disorders, affecting more than 50% of those younger than 5 years. Sleep breathing disorders were a frequent problem across all age groups. Oximetry was not diagnostic of sleep-disordered breathing or obvious seizures.
URI: http://ahro.austin.org.au/austinjspui/handle/1/18044
DOI: 10.1111/dmcn.13601
ORCID: 0000-0001-7969-4268
0000-0002-2311-2174
0000-0002-2859-132X
PubMed URL: 29110313
Type: Journal Article
Research Support, Non-U.S. Gov't
Appears in Collections:Journal articles

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