Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/18032
Title: Ejaculatory frequency and the risk of aggressive prostate cancer: Findings from a case-control study.
Authors: Papa, Nathan P;MacInnis, Robert J;English, Dallas R;Bolton, Damien M;Davis, Ian D;Lawrentschuk, Nathan;Millar, Jeremy L;Pedersen, John;Severi, Gianluca;Southey, Melissa C;Hopper, John L;Giles, Graham G
Affiliation: Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia
Department of Urology, Austin Health, Heidelberg, Australia
Monash University Eastern Health Clinical School, Box Hill, Australia; Eastern Health, Box Hill, Australia
Olivia Newton-John Cancer Research Institute, Melbourne, Australia
Department of Surgical Oncology, Peter MacCallum Cancer Institute, Melbourne, Australia
Alfred Health Radiation Oncology, The Alfred Hospital, Prahran, Australia
TissuPath, Melbourne, Australia
Department of Pathology, Genetic Epidemiology Laboratory, The University of Melbourne, Melbourne, Australia
0000-0001-8553-5618
Issue Date: Aug-2017
EDate: 2017-03-27
Citation: Urologic oncology 2017; 35(8): 530.e7-530.e13
Abstract: Recent literature reports inverse associations with ejaculator frequency and prostate cancer (PC). We sought to explore the relationship between ejaculatory frequency from ages 20 to 50 and subsequent development of aggressive PC. We conducted a case-control study sampling 2,141 men from private urology practices in Victoria, Australia. Cases were defined as men with high grade or high stage PC and controls being biopsy negative men. Ejaculation frequency recalled at age decades 20, 30, and 40 second was assessed by questionnaire. Unconditional multivariable logistic regression models were used to generate odds ratios (ORs). An inverse association with ejaculatory frequency at age 30 to 39 was observed (OR per 5-unit increase per week = 0.83, 95% CI: 0.72-0.96) but not at ages 20 to 29 (OR = 1.01, 95% CI: 0.89-1.14) or ages 40 to 49 (OR = 0.95, 95% CI: 0.81-1.12). This result differed between men with new sexual partners after age 30 (OR = 0.77, P = 0.009) and those with no new partners (OR = 0.97, P = 0.8) though the test for a difference between these estimates was not significant (P = 0.11). We found only weak evidence of an inverse association between ejaculatory frequency in the fourth decade of life and advanced PC, which was not significantly modified by number of new sexual partners. No relationship was found for ejaculatory frequency in the third and fifth decades of life.
URI: http://ahro.austin.org.au/austinjspui/handle/1/18032
DOI: 10.1016/j.urolonc.2017.03.007
ORCID: 0000-0002-3188-1803
0000-0002-5145-6783
PubMed URL: 28359743
Type: Journal Article
Research Support, Non-U.S. Gov't
Subjects: Case-control
Ejaculation
Epidemiology
Prostate
Prostate cancer
Appears in Collections:Journal articles

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