Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/18001
Title: Targeting Macrophages in Cancer: From Bench to Bedside.
Authors: Poh, Ashleigh R;Ernst, Matthias
Affiliation: Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia
La Trobe University School of Cancer Medicine, Heidelberg, Victoria, Australia
Issue Date: 2018
EDate: 2018-03-12
Citation: Frontiers in oncology 2018; 8: 49
Abstract: Macrophages are a major component of the tumor microenvironment and orchestrate various aspects of immunity. Within tumors, macrophages can reversibly alter their endotype in response to environmental cues, including hypoxia and stimuli derived from other immune cells, as well as the extracellular matrix. Depending on their activation status, macrophages can exert dual influences on tumorigenesis by either antagonizing the cytotoxic activity immune cells or by enhancing antitumor responses. In most solid cancers, increased infiltration with tumor-associated macrophages (TAMs) has long been associated with poor patient prognosis, highlighting their value as potential diagnostic and prognostic biomarkers in cancer. A number of macrophage-centered approaches to anticancer therapy have been investigated, and include strategies to block their tumor-promoting activities or exploit their antitumor effector functions. Integrating therapeutic strategies to target TAMs to complement conventional therapies has yielded promising results in preclinical trials and warrants further investigation to determine its translational benefit in human cancer patients. In this review, we discuss the molecular mechanisms underlying the pro-tumorigenic programming of macrophages and provide a comprehensive update of macrophage-targeted therapies for the treatment of solid cancers.
URI: http://ahro.austin.org.au/austinjspui/handle/1/18001
DOI: 10.3389/fonc.2018.00049
ORCID: 0000-0002-6399-1177
PubMed URL: 29594035
ISSN: 2234-943X
Type: Journal Article
Review
Subjects: cancer
immunotherapy
inflammation
macrophage polarization
macrophages
Appears in Collections:Journal articles

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