Please use this identifier to cite or link to this item:
Title: Retrospective evaluation of venous thromboembolism: Are all transient provoking events the same?
Authors: Chua, Chong Chyn;Lim, Hui Yin;Tacey, Mark;Nandurkar, Harshal;Ho, Prahlad W
Affiliation: Austin Health, Heidelberg, Victoria, Australia
Northern Health, Epping, Melbourne, Vic., Australia
University of Melbourne, Parkville, Vic., Australia
Australian Centre for Blood Diseases, Monash University, Melbourne, Vic., Australia
Monash University, Clayton, Vic., Australia
Issue Date: Jul-2017
EDate: 2017-05-24
Citation: European journal of haematology 2017; 99(1): 18-26
Abstract: Venous thromboembolism (VTE) provoked by transient risk factors has traditionally been classified as a single entity with lower risk of recurrence. We evaluated the association between different categories of transient provoking factors and the relative risk of recurrence. Retrospective evaluation of VTE events in non-cancer patients from July 2011 to December 2012 at two tertiary institutions in Australia with a minimum follow-up of 24 months. A total of 747 VTE cases were identified, and following exclusion of cases with mortality within 30 days of presentation (n=26), unprovoked cases (40.2%) had a higher risk of recurrence (4.6 vs 2.3/100 event-years, P=.01). Provoking factors included surgery (40.4%), injury (16.7%), medical-related factors including non-surgical hospitalisation or active infection (22.0%), travel (13.2%) and oestrogen related (6.5%). Air travel had the highest recurrence rate of 5.9/100 event-years, comparable to unprovoked VTE. VTE provoked by surgery showed lower recurrence rate at 1.8/100 event-years (P=.03). 62.5% of patients with provoked VTE recurred with an unprovoked event. Transient provoking factors for VTE are heterogeneous with varying potency and should not be considered a single entity. The high recurrence rate after travel-provoked VTE suggests that it is a "minor," if not negligible provoking factor with higher thrombotic predisposition.
DOI: 10.1111/ejh.12884
ORCID: 0000-0002-1373-7437
PubMed URL: 28321922
Type: Journal Article
Subjects: clot recurrence
epidemiological studies
provoking factors
venous thromboembolism
Appears in Collections:Journal articles

Files in This Item:
There are no files associated with this item.

Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.