Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/17947
Title: Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.
Authors: Anderson, Christopher D;Brown, Robert D;Butterworth, Adam S;Carty, Cara L;Chasman, Daniel I;Chen, Wei-Min;den Hoed, Marcel;Gustafsson, Stefan;Hassan, Ahamad;Heckbert, Susan R;Lange, Leslie A;O'Donnell, Martin J;Levi, Christopher R;Tai, E Shyong;Lemmens, Robin;Wakai, Kenji;Harris, Tamara B;DeStefano, Anita L;Johnson, Andrew D;Lorentzen, Erik;Soriano-Tárraga, Carolina;Chambers, John C;Cotlarciuc, Ioana;Havulinna, Aki S;Perola, Markus;Debette, Stephanie;Launer, Lenore J;Heitsch, Laura;Yang, Qiong;Traylor, Matthew;van der Laan, Sander W;Howard, George;Gottesman, Rebecca F;Fornage, Myriam;Magnusson, Patrik K;Trégouët, David A;Carrera, Caty;Dörr, Marcus;Nalls, Michael A;Touze, Emmanuel;He, Jiang;Duan, Qing;Sattar, Naveed;Smith, Albert;Kubo, Michiaki;Cullell, Natalia;Jian, Xueqiu;Correa, Adolfo;Dartigues, Jean-François;Woo, Daniel;Falcone, Guido J;Taylor, Kent D;Ogishima, Soichi;Maguire, Jane;Ellinor, Patrick T;Howson, Joanna M M;Ikram, M Arfan;Lind, Lars;Valdimarsson, Einar M;Williams, Stephen R;Arnett, Donna K;Koudstaal, Peter J;Ninomiya, Toshiharu;Grewal, Raji P;Labovitz, Daniel L;Iwasaki, Motoki;Ago, Tetsuro;Irvin, Marguerite R;Koplev, Simon;Peddareddygari, Leema Reddy;Sarnowski, Chloe;Ingelsson, Martin;Stefansson, Kari;Danesh, John;Lin, Wei-Yu;Norrving, Bo;Thorsteinsdottir, Unnur;Psaty, Bruce M;Ridker, Paul M;Ilinca, Andreea;Martinez-Majander, Nicolas;Lubitz, Steven A;Chowhan, Ayesha;Johnson, Julie A;Minegishi, Naoko;Caso, Valeria;Mosley, Thomas H;Sapkota, Bishwa R;Meschia, James F;Sanghera, Dharambir K;Satizabal, Claudia L;Tomppo, Liisa;Tiedt, Steffen;Kjartansson, Olafur;Bevan, Steve;Holliday, Elizabeth G;Buring, Julie E;Sarju, Ralhan;Tanaka, Hideo;Civelek, Mete;Roquer, Jaume;Rothwell, Peter M;Leys, Didier;Pezzini, Alessandro;Saleheen, Danish;Lindgren, Cecilia M;Kloss, Manja;Rice, Kenneth;Rabionet, Raquel;Kato, Norihiro;Kamouchi, Masahiro;Lioutas, Vasileios;Walters, Matthew;Choi, Seung Hoan;Mishra, Aniket;Tsugane, Shoichiro;Lewis, Cathryn M;McArdle, Patrick F;Ford, Ian;Lopez, Oscar L;Bustamante, Mariana;Gretarsdottir, Solveig;Kooperberg, Charles;Jousilahti, Pekka;Teumer, Alexander;Langenberg, Claudia;Longstreth, W T;Manichaikul, Ani;Krupinski, Jerzy;Christophersen, Ingrid E;Pera, Joanna;Strauch, Konstantin;Morris, Andrew P;Kalra, Lalit;Takai, Takako;Amin, Najaf;Laurie, Cathy C;Lee, Jin-Moo;Thorleifsson, Gudmar;Chong, Michael;Cheng, Yu-Ching;Matsuda, Koichi;Rundek, Tatjana;Rosand, Jonathan;Worrall, Bradford B;Sawada, Norie;Seshadri, Sudha;Romero, Jose R;Li, Linxin;Dichgans, Martin;Hozawa, Atsushi;Montaner, Joan;Jukema, J Wouter;Trompet, Stella;Codoni, Veronica;Völzke, Henry;Beiser, Alexa S;Kitazono, Takanari;Pileggi, Silvana;Thijs, Vincent N;Amouyel, Philippe;Boncoraglio, Giorgio B;van der Lee, Sven J;Schmidt, Reinhold;Langefeld, Carl D;Stott, David J;Muiño, Elena;Sharma, Pankaj;Reiner, Alexander P;Almgren, Peter;Ribasés, Marta;Rich, Stephen S;Smith, Nicholas L;Jern, Christina;Rannikmäe, Kristiina;Fernandez-Cadenas, Israel;Jackson, Rebecca D;Liu, Yong Mei;Sobue, Kenji;Björkegren, Johan L M;Kissela, Brett M;Ruusalepp, Arno;Cole, John W;Pulit, Sara L;Wareham, Nicholas J;Attia, John;Sacco, Ralph L;Hata, Jun;Rudd, Anthony G;Wiggins, Kerri L;Xu, Huichun;Sakaue, Saori;Hsu, Fang-Chi;Stine, O Colin;Delgado, Pilar;Rolfs, Arndt;Giese, Anne-Katrin;Adams, Hieab H H;Torres-Aguila, Nuria P;Salomaa, Veikko;Gurpreet, Wander S;Pedersen, Nancy L;Wolfe, Charles D A;Melander, Olle;Okada, Yukinori;Wassertheil-Smoller, Sylvia;Riba-Llena, Iolanda;Kamatani, Yoichiro;Lindgren, Arne G;van Duijn, Cornelia M;Tanislav, Christian;Wong, Quenna;Takeuchi, Fumihiko;Satoh, Mamoru;Rost, Natalia S;Rutten-Jacobs, Loes;Haessler, Jeffrey;Hamsten, Anders;Stanne, Tara;Schmidt, Carsten O;Aparicio, Hugo S;Berr, Claudine;Roselli, Carolina;Chauhan, Ganesh;Pastinen, Tomi;Rotter, Jerome I;Sargurupremraj, Muralidharan;Uitterlinden, Andre G;Sudlow, Cathie L M;Müller-Nurasyid, Martina;Keene, Keith L;Hopewell, Jemma C;Sigurdsson, Ásgeir;Yamaji, Taiki;Wilson, James G;Gudnason, Vilmundur;Ibanez, Laura;Jood, Katarina;Pare, Guillaume;Hoed, Marcel den;Elliott, Paul;Tatlisumak, Turgut;Engelter, Stefan T;Benavente, Oscar R;Mitchell, Braxton D;Bis, Joshua C;Sarin, Antti-Pekka;Kleindorfer, Dawn O;Slowik, Agnieszka;Bartz, Traci M;Weir, David;Sale, Michele M;Kooner, Jaspal S;Kanai, Masahiro;Parati, Eugenio A;Jiménez-Conde, Jordi;Kaffashian, Sara;Ay, Hakan;Hyacinth, Hyacinth I;Sibolt, Gerli;Malik, Rainer;Schadt, Eric E;Ingelsson, Erik;Markus, Hugh S;Cruchaga, Carlos;Makoto, Hirata;van der Harst, Pim;Tanno, Kozo;Yusuf, Salim;Engström, Gunnar;Strbian, Daniel;de Bakker, Paul I W;Rexrode, Kathryn M;Tzourio, Christophe;Kittner, Steven J;Schminke, Ulf;Delavaran, Hossein;Sasaki, Makoto
Affiliation: Centre for Brain Research, Indian Institute of Science, Bangalore, India
INSERM U1219 Bordeaux Population Health Research Center, University of Bordeaux, France
Stroke Research Group, Division of Clinical Neurosciences, University of Cambridge, Cambridge, UK
Department of Neurology, Institute for Neurodegenerative Disease, Bordeaux University Hospital, Bordeaux, France
Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan
Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan
Department of Neurology, Massachusetts General Hospital (MGH), Harvard Medical School, Boston, MA, USA
Laboratory of Experimental Cardiology, Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, University of Utrecht, Utrecht, the Netherlands
deCODE genetics/AMGEN Inc., Reykjavik, Iceland
Neuroscience Institute, SF Medical Center, Trenton, NJ, USA
Department of Biostatistics, University of Washington, Seattle, WA, USA
Center for Translational Science, George Washington University, Washington, DC, USA
Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Goteborg, Sweden
Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA
Clinical Research Facility, Department of Medicine, NUI Galway, Galway, Ireland
Department of Neurology, Mayo Clinic Rochester, Rochester, MN, USA
Department of Psychiatry, Hope Center Program on Protein Aggregation and Neurodegeneration (HPAN), Washington University School of Medicine, St. Louis, MO, USA
Laboratory of Epidemiology and Population Science, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
Department of Neurology and Rehabilitation Medicine, Skåne University Hospital, Lund, Sweden
Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA
Department of Epidemiology and Biostatistics, Imperial College London, London, UK
Department of Pediatrics, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
Bordeaux Population Health Research Center, INSERM, UMR 1219, Université Bordeaux, Bordeaux, France
Department of Neurology, Jagiellonian University, Krakow, Poland
Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
BHF Glasgow Cardiovascular Research Centre, Faculty of Medicine, Glasgow, UK
Clinical Gene Networks AB, Stockholm, Sweden..Department of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology Icahn School of Medicine at Mount Sinai, New York, NY, USA
Estonian Genome Center, University of Tartu, Tartu, Estonia
Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden
Clinical Gene Networks AB, Stockholm, Sweden..UPMC Univ. Paris 06, INSERM, UMR_S 1166, Team Genomics & Pathophysiology of Cardiovascular Diseases, Sorbonne Universités, Paris, France
Department of Neurology, IMIM-Hospital del Mar, and Universitat Autònoma de Barcelona, Barceloina, Spain
Department of Neurology, Justus Liebig University, Giessen, Germany..
Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, Japan
Department of Medical Sciences, Uppsala University, Uppsala, Sweden
Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, NY, USA
University of Kentucky College of Public Health, Lexington, KY, USA
Department of Pathophysiology, Institute of Biomedicine and Translation Medicine, University of Tartu, Tartu, Estonia
National Heart and Lung Institute, Imperial College London, London, UK
Genetic and Genomic Epidemiology Unit, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA
Department of Neurology, Mayo Clinic, Jacksonville, FL, USA
Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, San Antonio, TX, USA
Departments of Medicine, Pediatrics and Population Health Science, University of Mississippi Medical Center, Jackson, MS, USA
Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany
Boston University School of Public Health, Boston, MA, USA
Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA
VIB Center for Brain & Disease Research, University Hospitals Leuven, Department of Neurology, Leuven, Belgium
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA
Cardiovascular Research Center, MGH, Boston, MA, USA.. Department of Medical Research, Bærum Hospital, Vestre Viken Hospital Trust, Gjettum, Norway
Albrecht Kossel Institute, University Clinic of Rostock, Rostock, Germany
Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan
Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden
FIMM-Institute for Molecular Medicine Finland, Helsinki, Finland
School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA
Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands
Department of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
Department of Clinical Sciences, Lund University, Malmö, Sweden
Department of Immunology, Genetics and Pathology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden
Framingham Heart Study, Framingham, MA, USA
Integrated Cardio Metabolic Centre, Department of Medicine, Karolinska Institutet, Karolinska Universitetssjukhuset, Huddinge, Sweden
Beth Israel Deaconess Medical Center, Boston, MA, USA
INSERM, U1219, Bordeaux, France
Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Goteborg, Sweden
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Stroke Pharmacogenomics and Genetics, Fundacio Docència i Recerca MutuaTerrassa, Terrassa, Spain
Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
INSERM, U1061, Université Montpellier, Montpellier, France
Robertson Center for Biostatistics, University of Glasgow, Glasgow, UK
Center for Genomic Medicine, MGH, Boston, MA, USA
University of Newcastle and Hunter Medical Research Institute, New Lambton, New South Wales, Australia
Centre Hospitalier Université Lille, Epidemiology and Public Health Department, Lille, France
MEB, Karolinska Institutet, Stockholm, Sweden
Department of Neurology and Stroke Center, Basel University Hospital, Basel, Switzerland
Memory Impairment and Neurodegenerative Dementia Center, University of Mississippi Medical Center, Jackson, MS, USA
Center for Medical Systems Biology, Leiden, the Netherlands
Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Department of Neurology, Memory Clinic, Bordeaux University Hospital, Bordeaux, France
Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada
Montefiore Medical Center, Albert Einstein College of Medicine, New York, NY, USA
SGDP Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK
Department of Neurology, Erasmus University Medical Center, Rotterdam, the Netherlands
Department of Pathology and Genetics, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
Wake Forest School of Medicine, Wake Forest, NC, USA
Department of Neurology, Austin Health, Heidelberg, Victoria, Australia
Faculty of Medicine, University of Iceland, Reykjavik, Iceland
Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA
Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Harvard Medical School, Boston, MA, USA
Department of Cardiac Surgery, Tartu University Hospital, Tartu, Estonia
Department of Medicine I, Ludwig-Maximilians-Universität, Munich, Germany
Brain Center Rudolf Magnus, Department of Neurology, University Medical Center Utrecht, Utrecht, the Netherlands
Institute for Community Medicine, SHIP-KEF, University Medicine Greifswald, Greifswald, Germany
British Heart Foundation, Cambridge Centre of Excellence, Department of Medicine, University of Cambridge, Cambridge, UK
Department of Neurology, Helsinki University Hospital, Helsinki, Finland
Department of Clinical Neurosciences/Neurology, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK
Centre for Prevention of Stroke and Dementia, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK
Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA
Tohoku Medical Megabank Organization, Sendai, Japan
BioBank Japan, Laboratory of Clinical Sequencing, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan
Hero DMC Heart Institute, Dayanand Medical College & Hospital, Ludhiana, India
INSERM U 1171, CHU Lille, Université Lille, Lille, France
Karolinska Institutet, Stockholm, Sweden
Department of Clinical Sciences Lund, Neurology, Lund University, Lund, Sweden
Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA
Department of Clinical and Experimental Sciences, Neurology Clinic, University of Brescia, Brescia, Italy
John Hunter Hospital, Hunter Medical Research Institute and University of Newcastle, Newcastle, New South Wales, Australia
Division of Neurology, Faculty of Medicine, Brain Research Center, University of British Columbia, Vancouver, British Columbia, Canada
Broad Institute, Cambridge, MA, USA
Centre for Research in Environmental Epidemiology, Barcelona, Spain
Department of Pathophysiology, Institute of Biomedicine and Translation Medicine, Biomeedikum, University of Tartu, Tartu, Estonia
Department of Human Genetics, McGill University, Montreal, Quebec, Canada
Division of Geriatrics, School of Medicine, University of Mississippi Medical Center, Jackson, MS, USA
deCODE Genetics/Amgen, Inc., Reykjavik, Iceland
Department of Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
Institute of Cardiovascular Research, Royal Holloway University of London, London, UK, and Ashford and St Peters Hospital, Surrey, UK
Department of Epidemiology, University of Washington, Seattle, WA, USA
Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands
German Center for Neurodegenerative Diseases (DZNE), Munich, Germany
NIHR Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan
MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
J. Philip Kistler Stroke Research Center, Department of Neurology, MGH, Boston, MA, USA
Department of Neurology, Leeds General Infirmary, Leeds Teaching Hospitals NHS Trust, Leeds, UK
Neurovascular Research Laboratory, Vall d'Hebron Institut of Research, Neurology and Medicine Departments-Universitat Autònoma de Barcelona, Vall d'Hebrón Hospital, Barcelona, Spain
Landspitali University Hospital, Reykjavik, Iceland
University of Technology Sydney, Faculty of Health, Ultimo, New South Wales, Australia
Survey Research Center, University of Michigan, Ann Arbor, MI, USA
Department of Neurology, Università degli Studi di Perugia, Umbria, Italy
Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA
Center for Genomic Medicine, MGH, Boston, MA, USA.. J. Philip Kistler Stroke Research Center, Department of Neurology, MGH, Boston, MA, USA
Department of Neurosciences, Experimental Neurology, KU Leuven-University of Leuven, Leuven, Belgium
Sahlgrenska University Hospital, Gothenburg, Sweden
Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA, USA
Department of Genetics, University of North Carolina, Chapel Hill, NC, USA
Wellcome Trust Centre for Human Genetics, Oxford, UK
Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands
Department of Neurology, University of Washington, Seattle, WA, USA
Department of Neurology, University of Maryland School of Medicine and Baltimore VAMC, Baltimore, MD, USA
Children's Research Institute, Children's National Medical Center, Washington, DC, USA
Department of Neurology, Medical University of Graz, Graz, Austria..
Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Glasgow, UK
Northern Institute for Cancer Research, Newcastle University, Newcastle, UK
School of Life Science, University of Lincoln, Lincoln, UK
Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany
IBE, Faculty of Medicine, LMU Munich, Munich, Germany
ICAN Institute for Cardiometabolism and Nutrition, Paris, France
Department of Neurology, University of Virginia School of Medicine, Charlottesville, VA, USA..
Department of Health Services, University of Washington, Seattle, WA, USA
Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA
Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK
Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA
Division of Emergency Medicine, and Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA
School of Medicine, Dentistry and Nursing at the University of Glasgow, Glasgow, UK
Department of Neurology, University of Virginia, Charlottesville, VA, USA
Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA
Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA
Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA
Translational Genomics Unit, Department of Oncology, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
Department of Cardiology, Ealing Hospital NHS Trust, Southall, UK
Data Tecnica International, Glen Echo, MD, USA
Hospital Universitari Mutua Terrassa, Terrassa (Barcelona), Spain
University of Caen Normandy, Caen, France
DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany
Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
Clinical Neurosciences, Neurology, University of Helsinki, Helsinki, Finland
Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore
Department of Internal Medicine, Section Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands
Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK
National Institute for Health Research Comprehensive Biomedical Research Centre, Guy's & St. Thomas' NHS Foundation Trust and King's College London, London, UK
Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK
Department of Pediatrics, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA..
National Institute for Health and Welfare, Helsinki, Finland..
Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands
Department of Neurology, Caen University Hospital, Caen, France
Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany
Icelandic Heart Association Research Institute, Kopavogur, Iceland
National Heart, Lung and Blood Research Institute, Division of Intramural Research, Population Sciences Branch, Framingham, MA, USA
MRC-PHE Centre for Environment and Health, School of Public Health, Department of Epidemiology and Biostatistics and the NIHR Imperial Biomedical Research Centre, Imperial College London, London, UK
Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA
Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden
Stroke Division, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Heidelberg, Victoria, Australia
Icelandic Heart Association, Reykjavik, Iceland
Department of Cerebrovascular Diseases, Fondazione IRCCS Istituto Neurologico 'Carlo Besta', Milan, Italy
Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK
Psychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addictions, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Biomedical Network Research Centre on Mental Health (CIBERSAM), Barcelona, Spain
Department of Biostatistics, University of Liverpool, Liverpool, UK
Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA
Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Department of Medical and Molecular Genetics, King's College London, London, UK
Department of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology Icahn School of Medicine at Mount Sinai, New York, NY, USA
DZHK, Greifswald, Germany
Department of Neurology, Radiology, and Biomedical Engineering, Washington University School of Medicine, St. Louis, MO, USA
Boston University School of Medicine, Boston, MA, USA
Department of Neurology, University Medicine Greifswald, Greifswald, Germany..
Department of Public Health, Bordeaux University Hospital, Bordeaux, France
Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA
Neurovascular Research Laboratory. Vall d'Hebron Institut of Research, Neurology and Medicine Departments-Universitat Autònoma de Barcelona. Vall d'Hebrón Hospital, Barcelona, Spain
Division of Health and Social Care Research, King's College London, London, UK
Department of Epidemiology, University of Maryland School of Medicine, Baltimore, MD, USA
Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany
Bioinformatics Core Facility, University of Gothenburg, Gothenburg, Sweden
Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands
Department of Genetics, Microbiology and Statistics, University of Barcelona, Barcelona, Spain
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
Group Health Research Institute, Group Health Cooperative, Seattle, WA, USA.. Seattle Epidemiologic Research and Information Center, VA Office of Research and Development, Seattle, WA, USA
Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, USA
National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK
Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL, USA
IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain
AA Martinos Center for Biomedical Imaging, Department of Radiology, MGH, Harvard Medical School, Boston, MA, USA
Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
Munich Cluster for Systems Neurology (SyNergy), Munich, Germany
Oklahoma Center for Neuroscience, Oklahoma City, OK, USA
INSERM, Institut Pasteur de Lille, LabEx DISTALZ-UMR1167, Risk Factors and Molecular Determinants of Aging-Related Diseases, Université Lille, Lille, France
Department of Internal Medicine and the Center for Clinical and Translational Science, Ohio State University, Columbus, OH, USA
Neurorehabilitation Unit, University of Basel and University Center for Medicine of Aging and Rehabilitation Basel, Felix Platter Hospital, Basel, Switzerland
Department of Medical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands
Cardiovascular Health Research Unit, Departments of Biostatistics and Medicine, University of Washington, Seattle, WA, USA
Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
Aflac Cancer and Blood Disorder Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA
Department of Neurology, Yale University School of Medicine, New Haven, CT, USA
Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA
Issue Date: Apr-2018
EDate: 2018
Citation: Nature genetics 2018-04; 50(4): 524-537
Abstract: Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown. We conducted a multiancestry genome-wide-association meta-analysis in 521,612 individuals (67,162 cases and 454,450 controls) and discovered 22 new stroke risk loci, bringing the total to 32. We further found shared genetic variation with related vascular traits, including blood pressure, cardiac traits, and venous thromboembolism, at individual loci (n = 18), and using genetic risk scores and linkage-disequilibrium-score regression. Several loci exhibited distinct association and pleiotropy patterns for etiological stroke subtypes. Eleven new susceptibility loci indicate mechanisms not previously implicated in stroke pathophysiology, with prioritization of risk variants and genes accomplished through bioinformatics analyses using extensive functional datasets. Stroke risk loci were significantly enriched in drug targets for antithrombotic therapy.
URI: http://ahro.austin.org.au/austinjspui/handle/1/17947
DOI: 10.1038/s41588-018-0058-3
ORCID: 0000-0001-6624-8621
0000-0002-0311-8472
0000-0003-3223-885X
0000-0001-6888-1404
0000-0002-0473-0241
0000-0001-9088-234X
0000-0002-9501-600X
0000-0002-0276-2899
0000-0001-8081-428X
0000-0001-5894-0351
0000-0002-4787-8959
0000-0003-0372-8585
0000-0002-3246-8359
0000-0001-5165-4408
0000-0002-8249-8476
0000-0002-9267-7988
0000-0002-7315-7899
0000-0003-2749-1279
0000-0002-3658-1375
0000-0002-7892-8808
0000-0002-8586-5614
0000-0002-8141-0284
0000-0001-9084-7800
0000-0002-6141-4712
0000-0001-5267-6756
0000-0002-2067-0533
0000-0002-2713-686X
0000-0002-7511-5684
0000-0003-3185-5661
0000-0002-7531-2354
0000-0001-6193-020X
0000-0001-8748-5597
0000-0002-0654-387X
0000-0003-3687-2508
0000-0002-2502-3669
0000-0002-6614-8417
PubMed URL: 29531354
Type: Journal Article
Appears in Collections:Journal articles

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