Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/17934
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dc.contributor.authorRoswall, Pernilla-
dc.contributor.authorBocci, Matteo-
dc.contributor.authorBartoschek, Michael-
dc.contributor.authorLi, Hong-
dc.contributor.authorKristiansen, Glen-
dc.contributor.authorJansson, Sara-
dc.contributor.authorLehn, Sophie-
dc.contributor.authorSjölund, Jonas-
dc.contributor.authorReid, Steven-
dc.contributor.authorLarsson, Christer-
dc.contributor.authorEriksson, Pontus-
dc.contributor.authorAnderberg, Charlotte-
dc.contributor.authorCortez, Eliane-
dc.contributor.authorSaal, Lao H-
dc.contributor.authorOrsmark-Pietras, Christina-
dc.contributor.authorCordero, Eugenia-
dc.contributor.authorHaller, Bengt Kristian-
dc.contributor.authorHäkkinen, Jari-
dc.contributor.authorBurvenich, Ingrid J G-
dc.contributor.authorLim, Elgene-
dc.contributor.authorOrimo, Akira-
dc.contributor.authorHöglund, Mattias-
dc.contributor.authorRydén, Lisa-
dc.contributor.authorMoch, Holger-
dc.contributor.authorScott, Andrew M-
dc.contributor.authorEriksson, Ulf-
dc.contributor.authorPietras, Kristian-
dc.date2018-05-12-
dc.date.accessioned2018-06-21T05:42:07Z-
dc.date.available2018-06-21T05:42:07Z-
dc.date.issued2018-05-
dc.identifier.citationNature medicine 2018; 24(4): 463-473-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/17934-
dc.description.abstractBreast tumors of the basal-like, hormone receptor-negative subtype remain an unmet clinical challenge, as there is high rate of recurrence and poor survival in patients following treatment. Coevolution of the malignant mammary epithelium and its underlying stroma instigates cancer-associated fibroblasts (CAFs) to support most, if not all, hallmarks of cancer progression. Here we delineate a previously unappreciated role for CAFs as determinants of the molecular subtype of breast cancer. We identified paracrine crosstalk between cancer cells expressing platelet-derived growth factor (PDGF)-CC and CAFs expressing the cognate receptors in human basal-like mammary carcinomas. Genetic or pharmacological intervention of PDGF-CC activity in mouse models of cancer resulted in conversion of basal-like breast cancers into a hormone receptor-positive state that enhanced sensitivity to endocrine therapy in previously resistant tumors. We conclude that specification of breast cancer to the basal-like subtype is under microenvironmental control and is therapeutically actionable.-
dc.language.isoeng-
dc.titleMicroenvironmental control of breast cancer subtype elicited through paracrine platelet-derived growth factor-CC signaling.-
dc.typeJournal Article-
dc.identifier.journaltitleNature medicine-
dc.identifier.affiliationDivision of Translational Cancer Research, Department of Laboratory Medicine, Lund University, Lund, Sweden-
dc.identifier.affiliationUniversity of New South Wales, Sydney, New South Wales, Australiaen
dc.identifier.affiliationGarvan Institute of Medical Research, Sydney, New South Wales, Australiaen
dc.identifier.affiliationInstitute of Pathology, University Hospital Bonn, Bonn, Germany-
dc.identifier.affiliationDivision of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden-
dc.identifier.affiliationDivision of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden-
dc.identifier.affiliationDivision of Oncology and Pathology, Department of Clinical Sciences, Lund University, Lund, Sweden-
dc.identifier.affiliationOlivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia-
dc.identifier.affiliationDepartment of Pathology and Oncology, Juntendo University School of Medicine, Tokyo, Japan-
dc.identifier.affiliationDepartment of Pathology and Molecular Pathology, University Hospital Zürich, Zürich, Switzerland-
dc.identifier.affiliationSchool of Cancer Medicine, La Trobe University, Melbourne, Victoria, Australia-
dc.identifier.doi10.1038/nm.4494-
dc.identifier.orcid0000-0002-0815-1896-
dc.identifier.orcid0000-0002-8466-9179-
dc.identifier.orcid0000-0002-4439-3980-
dc.identifier.pubmedid29529015-
dc.type.austinJournal Article-
local.name.researcherScott, Andrew M
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptMolecular Imaging and Therapy-
crisitem.author.deptOlivia Newton-John Cancer Research Institute-
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