Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/17845
Title: Health-related quality of life in idiopathic pulmonary fibrosis: Data from the Australian IPF Registry.
Authors: Glaspole, Ian N;Chapman, Sally A;Cooper, Wendy A;Ellis, Samantha J;Goh, Nicole S L;Hopkins, Peter M;Macansh, Sacha;Mahar, Annabelle;Moodley, Yuben P;Paul, Eldho;Reynolds, Paul N;Walters, E Haydn;Zappala, Christopher J;Corte, Tamera J
Affiliation: Department of Allergy, Immunology and Respiratory Medicine, The Alfred Hospital, Melbourne, Victoria, Australia
Department of Medicine, Monash University, Melbourne, Victoria, Australia
Department of Medicine, Royal Adelaide Hospital, Adelaide, South Australia, Australia
Department of Anatomical Pathology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia
Department of Pathology, University of Sydney, Sydney, New South Wales, Australia
School of Medicine, University of Western Sydney, Sydney, New South Wales, Australia
Department of Radiology, The Alfred Hospital, Melbourne, Victoria, Australia
Institute of Breathing and Sleep, Austin Hospital, Melbourne, Victoria, Australia
Department of Thoracic Medicine, Prince Charles Hospital, Brisbane, Queensland, Australia
Australian IPF Registry, Lung Foundation of Australia, Brisbane, Queensland, Australia
Department of Respiratory Medicine, Fiona Stanley Hospital, Perth, Western Australia, Australia
Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia
Clinical Haematology Department, The Alfred Hospital, Melbourne, Victoria, Australia
NHMRC CRE for Chronic Respiratory Disease, University of Tasmania, Hobart, Tasmania, Australia
Royal Brisbane & Women's Hospital, Brisbane, Queensland, Australia
Department of Respiratory Medicine, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia
Issue Date: Jul-2017
EDate: 2017-02-06
Citation: Respirology (Carlton, Vic.) 2017; 22(5): 950-956
Abstract: Studies analysing the effect of worsening pulmonary physiological impairment in idiopathic pulmonary fibrosis (IPF) with respect to quality of life have been limited to single centres or highly selected trial populations. The aim of this study was to determine the principal determinants of baseline and longitudinal health-related quality of life (HRQoL) in a large unselected IPF population. We used the Australian IPF Registry to examine the relationship between HRQoL, measured using the St George Respiratory Questionnaire (SGRQ), and demographic features, physiological features, co-morbidities and symptoms. Linear regression analysis was performed to identify predictors of baseline HRQoL, linear mixed model analysis to determine the effect of time and forced vital capacity (FVC) on SGRQ and Cox proportional hazards regression to examine the relationship between HRQoL and all-cause mortality. Baseline data from 516 patients were available (347 males; mean (SD) age: 71.3 ± 8.6 years). Univariate analysis showed significant associations between HRQoL and demographic, clinical and physiological features. However, multivariate analysis demonstrated independent associations only between SGRQ and dyspnoea (University of California San Diego Shortness of Breathlessness Questionnaire (UCSD-SOBQ); R2 = 0.71, P < 0.0001), cough severity (visual analogue scale; R2 = 0.06, P < 0.0001) and depression (Hospital Anxiety and Depression Scale; R2 = 0.04, P < 0.0001). Linear mixed-effects modelling of combined baseline and longitudinal data confirmed these associations, as well as for FVC% predicted (P = 0.005). Multivariate Cox proportionate-proportional hazards regression analysis demonstrated no association between HRQoL and risk of mortality. Cough, dyspnoea and depression are major symptomatic determinants of HRQoL in IPF. FVC decline is associated with worsening HRQoL.
URI: http://ahro.austin.org.au/austinjspui/handle/1/17845
DOI: 10.1111/resp.12989
ORCID: 0000-0002-5118-2890
PubMed URL: 28166611
Type: Journal Article
Research Support, Non-U.S. Gov't
Subjects: cough
dyspnoea
forced vital capacity
pulmonary fibrosis
quality of life
Appears in Collections:Journal articles

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