Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/17840
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dc.contributor.authorChiang, Cherie Y-
dc.contributor.authorZebaze, Roger M D-
dc.contributor.authorWang, Xiao-Fang-
dc.contributor.authorGhasem-Zadeh, Ali-
dc.contributor.authorZajac, Jeffrey D-
dc.contributor.authorSeeman, Ego-
dc.date2018-
dc.date.accessioned2018-06-18T00:00:09Z-
dc.date.available2018-06-18T00:00:09Z-
dc.date.issued2018-02-28-
dc.identifier.citationJournal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research 2018; online first: 28 Februaryen_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/17840-
dc.description.abstractReduced bone mineral density (BMD) may be due to reduced mineralized bone matrix volume, incomplete secondary mineralization, or reduced primary mineralization. Because bone biopsy is invasive, we hypothesized that noninvasive image acquisition at high resolution can accurately quantify matrix mineral density (MMD). Quantification of MMD was confined to voxels attenuation photons above 80% of that produced by fully mineralized bone matrix because attenuation at this level is due to variation in mineralization, not porosity. To assess accuracy, 9 cadaveric distal radii were imaged at a voxel size of 82 microns using high-resolution peripheral quantitative computed tomography (HR-pQCT; XtremeCT, Scanco Medical AG, Bruttisellen, Switzerland) and compared with VivaCT 40 (µCT) at 19-micron voxel size. Associations between MMD and porosity were studied in 94 healthy vitamin D-replete premenopausal women, 77 postmenopausal women, and in a 27-year-old woman with vitamin D-dependent rickets (VDDR). Microstructure and MMD were quantified using StrAx (StraxCorp, Melbourne, Australia). MMD measured by HR-pQCT and µCT correlated (R = 0.87; p < 0.0001). The precision error for MMD was 2.43%. Cortical porosity and MMD were associated with age (r2  = 0.5 and -0.4, respectively) and correlated inversely in pre- and postmenopausal women (both r2  = 0.9, all p < 0.001). Porosity was higher, and MMD was lower, in post- than in premenopausal women (porosity 40.3% ± 7.0 versus 34.7% ± 3.5, respectively; MMD 65.4% ± 1.8 versus 66.6% ± 1.4, respectively, both p < 0.001). In the woman with VDDR, MMD was 5.6 SD lower and porosity was 5.6 SD higher than the respective trait means in premenopausal women. BMD was reduced (Z-scores femoral neck -4.3 SD, lumbar spine -3.8 SD). Low-radiation HR-pQCT may facilitate noninvasive quantification of bone's MMD and microstructure in health, disease, and during treatment. © 2018 American Society for Bone and Mineral Research.en_US
dc.language.isoeng-
dc.subjectBONE QCT/MICRO-CTen_US
dc.subjectMATRIX MINERALIZATIONen_US
dc.subjectOSTEOMALACIA AND RICKETSen_US
dc.subjectOSTEOPOROSISen_US
dc.titleCortical Matrix Mineral Density Measured Noninvasively in Pre- and Postmenopausal Women and a Woman With Vitamin D-Dependent Rickets.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleJournal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Researchen_US
dc.identifier.affiliationEndocrinologyen_US
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Parkville, Australiaen_US
dc.identifier.affiliationInstitute of Health and Ageing, Australian Catholic University, Melbourne, Australiaen_US
dc.identifier.doi10.1002/jbmr.3415en_US
dc.type.contentTexten_US
dc.identifier.orcid0000-0002-9392-6771en_US
dc.identifier.orcid0000-0002-9692-048Xen_US
dc.identifier.pubmedid29489033-
dc.type.austinJournal Article-
local.name.researcherChiang, Cherie Y
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptPathology-
crisitem.author.deptEndocrinology-
crisitem.author.deptEndocrinology-
crisitem.author.deptEndocrinology-
crisitem.author.deptMedicine (University of Melbourne)-
crisitem.author.deptEndocrinology-
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